Ingmar Glauche

This paper develops a minimal mathematical model to predict treatment-free remission in chronic myeloid leukemia using leukemic fitness, and proposes adaptive therapy strategies based on this parameter.

The paper uses stochastic models to analyze clonal data from non-human primates, showing that HSC heterogeneity and quiescence are critical for long-term hematopoiesis.

The paper identifies a redox-sensitive cysteine in p21 that regulates its interaction with CDKs, controlling cell cycle progression and proliferation through a feedback loop.

The paper develops a mathematical model to analyze the timeline of CAR-T cell therapy and macrophage-mediated cytokine release syndrome, identifying key mechanisms and parameters influencing treatment outcomes.

This paper develops a model integrating tumor-immune dynamics to predict treatment-free remission in CML patients using time-course data on NK cells and tumor load.

TraCurate curates and annotates cell tracking data from time-lapse microscopy, improving accuracy with minimal user input.

The paper uses a mathematical model to analyze megakaryopoiesis in TPO receptor-deficient and overexpressed mice, identifying strain-dependent parameters and suggesting an unknown control mechanism.

The paper introduces genBaRcode, an R package for analyzing genetic barcode data, offering error correction, visualization, and a GUI for reproducible analysis.

The paper uses a mathematical model to classify CML patients based on immune response dynamics following TKI dose alterations, identifying different mechanisms for achieving treatment-free remission.

This study uses ODE models to analyze immune-leukemia interactions in CML treatment, showing that qualitative criteria outperform quantitative ones in identifying biologically relevant models.

This study develops an in-silico model to explore how hematopoietic stem cells (HSCs) respond to varying demands and aging, showing that internal feedback between HSCs and progenitors explains homeostasis and aging-related changes.