Distinct modes of N-terminal remodeling through a conserved inhibitor pocket in connexin-46/50
Joshua M. Jarodsky, Janette B. Myers, Steve Reichow
This study reveals how two distinct inhibitors affect the conserved N-terminal docking groove of connexin-46/50 gap junctions, leading to different conformational changes and providing structural insights into broad isoform activity.
bioRxiv · Oct 27, 2026 · PreprintBiophysics