Joshua M. Jarodsky

This study reveals how two distinct inhibitors affect the conserved N-terminal docking groove of connexin-46/50 gap junctions, leading to different conformational changes and providing structural insights into broad isoform activity.

This study uses cryo-EM to reveal how calcium binding to connexin-46/50 gap junctions induces structural changes leading to pore collapse and gating.

This study determines the structure of multi-channel connexin-46/50 gap junction assemblies, revealing lipid-mediated channel organization and refined single-channel structure.

This study uses cryo-EM to reveal how lipid-mediated pH changes gate connexin-46/50 gap junctions, showing reversible structural transitions under acidic conditions.