De novo Identification of DNA Modifications Enabled by Genome-Guided Nanopore Signal Processing
Marcus H. Stoiber, Joshua Quick, Rob S Egan, Ji Eun Lee, S Celniker, Robert K. Neely, Nicholas James Loman, Len A. Pennacchio, James B. Brown
Base-by-base tests of raw nanopore current, native versus amplified DNA, detect 4mC, 5mC and 6mA without training data, recovering seven methylases' motifs (AUC 0.62–0.97).
bioRxiv · Apr 10, 2017 · PreprintBioinformatics✦ In-depth digest