Nanopore and Nanochannel Transport Studies

Extreme Slowdown of dsDNA and RNA:DNA Hybrids in Solid-state Nanopores for LiCl concentrations above 4 mol/L

The paper shows that increasing LiCl concentration beyond 4 mol/L significantly increases translocation time for dsDNA and RNA:DNA hybrids in solid-state nanopores, improving barcode sensing resolution.

Digital molecular kinetics enabled by large-scale nanopore arrays for multidimensional biophysical profiling

This paper introduces a digital molecular kinetics platform using large-scale nanopore arrays to overcome limitations of traditional methods like SPR, enabling comprehensive thermodynamic-kinetic profiling and improved detection of molecular interactions.

Single molecule nanopore sensing across a liquid-solid interface

This paper demonstrates single-molecule nanopore sensing using a solid polymer electrolyte instead of liquid electrolytes, enhancing sensitivity and enabling robust, portable sensing platforms.

Sample preparation for direct nanopore based protein identification via tryptic peptide recognition

This paper introduces a sample preparation workflow (SP3) that enables nanopore-based protein identification by decoupling proteolysis from interfering components, demonstrating its effectiveness with tryptic digests of myelin basic protein.

A strategy for ionic current analysis of nanopore protein readouts

This paper develops a computational strategy for analyzing nanopore ionic current signals from synthetic proteins, achieving high accuracy in charge-based classification of amino acids.

Empirical Validation of Composite Fractional Noise Models in Nanopore Signals

This study empirically validates a composite fractional noise model for nanopore signals across diverse experimental conditions, showing it accurately captures noise structure and separates deterministic from stochastic components.

Breaking Pore Symmetry to Prolong DNA Residence in Solid-State Nanopores

This paper demonstrates that tilting solid-state nanopores increases DNA dwell time by altering electric field distribution and DNA motion, enhancing single-molecule sensing capabilities.

Characterization of Single Ribosomes and Virus Particles with Large-Diameter Perfringolysin O Nanopores

This paper introduces PFO nanopores for label-free, single-particle analysis of large biomolecules, enabling characterization of virus particles and ribosomes.

Dilatable DNA origami nanopores as nuclear pore mimics

This paper develops DNA origami nanopores that mimic nuclear pore complexes, showing tunable size and transport selectivity.

Counterions, Polarization and Pore Hydration Relay Drive Ion Permeation through Hydrophobic Pore Formed by the MERS Coronavirus E Protein

The paper investigates ion permeation through a hydrophobic pore formed by the MERS-CoV E protein, revealing that counterions, polarization, and pore hydration collectively enable efficient ion transport.

Controlling Molecular Transport through Nanopores by Dynamic Aperture Sizing

This paper introduces a dynamically reconfigurable nanopore, PEIN, enabling controlled molecular transport and demonstrating size-selective gating with sub-nanometre precision.

Single-Molecule Nanopore Profiling of p53-TAD Conformational Dynamics, Interactions, and Inhibition

This study uses a nanopore platform to analyze the conformational dynamics and interactions of p53-TAD, showing how a mutation and a drug affect its structure and binding.

Subtyping active-site inhibitor binding mode to Abl kinase using super-resolution nanopore tweezers.

This paper introduces a nanopore tweezers platform to subtype Abl kinase inhibitors by resolving ionic current signatures, achieving high classification accuracy without structural determination.

Single-Molecule Proteomics via a Dynamic Translocase and Physics-Informed Machine Learning

This paper introduces a dynamic translocase and physics-informed machine learning to resolve isobaric amino acids at the single-molecule level with high accuracy.

Nanopore-based sequence deconvolution of diverse glycosaminoglycans

This paper develops a nanopore-based method to deconvolute glycosaminoglycan structures at single-molecule resolution, achieving high precision in detecting sulfate groups and stereochemistry.

A nanoconfined liquid-in-ice aqueous regime for time-stretched single-molecule dynamics

This paper demonstrates a nanoconfined liquid-in-ice environment that enables real-time single-molecule dynamics measurements in deeply subzero conditions by overcoming water freezing limitations.

A pyramidal silicon nanopore for single misfolded Tau protein characterisation

This paper presents a pyramidal silicon nanopore for label-free characterisation of misfolded Tau proteins using resistive pulse sensing, enabling discrimination of different Tau species based on electrical fingerprints.

Nanopore Electrometry Resolves Peptide Charge Patterns beyond Ionic-Current Blockade

This study shows that localized electric-field measurements in nanopore sensing can capture peptide charge patterns more effectively than ionic-current blockade, enabling better peptide discrimination.

Beyond the Static Caliper: Dynamical Translocases and the Mathematical Imperative for Single-Molecule Proteomics

This paper proposes dynamical translocases and Physics-Informed Machine Learning to overcome biophysical limitations in single-molecule proteomics, achieving >90% accurate amino acid classification.

Generative design of programmable asymmetric β-barrel nanopores

This paper introduces a generative AI framework for designing transmembrane β-barrel nanopores with customizable properties for ion sensing, DNA translocation, and transport.

A generalizable codesigned platform for solid-state nanopore sensing beyond the capacitive-noise constraints

The paper introduces a co-designed nanopore sensing platform that overcomes noise limitations to recover high-resolution molecular data from high-bandwidth measurements.

Chemically tunable permeability of engineered alpha-Hemolysin in synthetic cells

This paper develops a method to tune nanopore permeability using chemically modified alpha-hemolysin in synthetic cells.

A framework for peptide identification on commercial nanopore sequencing platforms

This paper presents a framework for peptide identification using commercial nanopore sequencing platforms, achieving single-amino-acid resolution and reliable performance across sequencing runs.

DamageFormer: a damage-aware multimodal deep learning framework for DNA lesion identification from nanopore sequencing

DamageFormer detects and localizes DNA lesions from nanopore sequencing with high accuracy and generalization to unseen damage types.

OpenBase: a universal framework for high-accuracy single-molecule detection of diverse non-canonical DNA bases using nanopore sequencing

OpenBase provides a framework for high-accuracy detection of diverse non-canonical DNA bases using nanopore sequencing through standardized training data and deep learning models.

Nanopore event detection in a simple and adaptive way

This paper introduces a simple, fast, and adaptable cluster-based event detection algorithm for nanopore signals, showing improved efficiency and reduced noise in biological nanopore data.

Graph-based learning and read-out of nanopore translocation event signals

This paper develops a graph-based framework for label-free detection of nanopore translocation events, showing it can predict event morphology across a range of voltages.

Engineered Channel Asymmetry Extends Hydrogen-Bonding Networks for Proton Conduction

This paper engineers proton-conductive channels by introducing asymmetry in polar sidechains to enhance hydrogen-bonding network connectivity and proton transport efficiency.

Detection of attomolar concentration of heart-type fatty acid binding protein using ion current rectification sensing with conical SiO2 nanopores

This study develops a nanopore biosensor for detecting H-FABP at attomolar concentrations with high sensitivity and selectivity.

β-barrel nanopores designed for insertion into thick block copolymer membranes

This paper redesigns β-barrel nanopores for stable insertion into thick block copolymer membranes, enabling efficient detection and translocation of biomolecules.