Robert K. Neely

Expansion microscopy allows quantitative characterisation of structural organisation of platelet aggregates

This study uses expansion microscopy to quantitatively analyze the structure of platelet aggregates under normal and perturbed conditions.

A modified methyl transferase cofactor to selectively disable gene expression in E. coli

The paper demonstrates that AdoHcy azide modification selectively disables gene expression in E. coli by causing transcriptional steric inhibition.

Epigenomic profiling of active regulatory elements by enrichment of unmodified CpG dinucleotides

This paper introduces Active-Seq, a method to profile hypomethylated regions by enriching non-modified CpG sites, showing its effectiveness in various DNA sources.

Imaging Nanoscale Nuclear Structures with Expansion Microscopy

This study demonstrates isotropic expansion of the nucleus using expansion microscopy to investigate nanoscale DNA damage response structures.

DNA barcodes for rapid, whole genome, single-molecule analyses

The paper introduces DNA barcodes for analyzing complex genomic mixtures, enabling identification of specific DNA molecules, strain typing, and virus detection in human genomic backgrounds.

De novo Identification of DNA Modifications Enabled by Genome-Guided Nanopore Signal Processing

Base-by-base tests of raw nanopore current, native versus amplified DNA, detect 4mC, 5mC and 6mA without training data, recovering seven methylases' motifs (AUC 0.62–0.97).