Congenital Ear and Nasal Anomalies

Integrated CHARGE syndrome models reveal epigenetic modulators of reproductive phenotypes

The paper identifies epigenetic modulators that rescue reproductive defects in CHARGE syndrome across species by targeting SEMA signaling pathways.

Multi-omic analyses identify molecular targets of Chd7 that mediate CHARGE syndrome model phenotypes

The paper identifies Chd7 target genes that mediate CHARGE syndrome phenotypes using transcriptomic and proteomic analysis of zebrafish brain tissue.

Abnormal craniofacial and spinal bone development with col2a1a depletion in a zebrafish model of CHARGE syndrome

This study identifies skeletal abnormalities in chd7-/- zebrafish, linking col2a1a depletion to craniofacial and spinal bone development defects in CHARGE syndrome.

Morphological and sensorimotor phenotypes in a zebrafish CHARGE syndrome model are domain-dependent

The paper shows that mutation location in chd7 affects morphological and behavioral phenotypes in a zebrafish CHARGE syndrome model.

ANALYSIS OF CHD-7 DEFECTIVE DAUER NEMATODES IMPLICATES COLLAGEN MISREGULATION IN CHARGE SYNDROME FEATURES.

This paper identifies chd-7's role in collagen regulation in nematodes and vertebrates, linking it to CHARGE syndrome features through extracellular matrix misregulation.