Shunmoogum A. Patten

Targeting calpastatin pharmacologically restores synaptic proteolysis and preserves motor neurons survival and function in C9orf72 ALS

This study shows that restoring calpastatin activity improves motor neuron function and survival in C9orf72 ALS models by enhancing synaptic proteolysis and NMJ integrity.

A genus-wide interaction atlas across NS4B orthologues identifies a conserved role for UFMylation in orthoflavivirus replication

This study identifies conserved interactions of NS4B with the UFMylation pathway across orthoflaviviruses, revealing a novel role for UFMylation in viral replication and suggesting it as a therapeutic target.

Gap junction communication regulates luminal-myoepithelial crosstalk and cell differentiation in a bi-layered human mammary epithelial cell model

This study develops a bilayered co-culture model of human mammary epithelial cells and shows that gap junction communication is essential for lineage-specific differentiation.

RFC1 regulates the expansion of neural progenitors in the developing zebrafish cerebellum

This study investigates RFC1's role in zebrafish cerebellar development, showing its necessity for neural progenitor genomic integrity and neurogenesis.

Abnormal craniofacial and spinal bone development with col2a1a depletion in a zebrafish model of CHARGE syndrome

This study identifies skeletal abnormalities in chd7-/- zebrafish, linking col2a1a depletion to craniofacial and spinal bone development defects in CHARGE syndrome.