363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
David M. Howard, Mark J. Adams, Toni‐Kim Clarke…·Andrew Mark McIntosh
A meta-analysis of 807,553 people from 23andMe, UK Biobank and PGC finds 102 depression variants. 87 of them replicate in 1,306,354 individuals, and heritability is enriched in prefrontal brain regions.
Ditte Demontis, Raymond Kenney Walters, Joanna Martin…·Benjamin M. Neale
Genome-wide association meta-analysis of 20,183 ADHD cases and 35,191 controls finds 12 significant loci; signal concentrates in conserved regions, constrained genes, and CNS regulatory elements.
Sara L. Pulit, Charli E Harlow, Andrew P. Morris…·Cecilia M. Lindgren
Meta-analysis of waist-to-hip ratio adjusted for BMI in 694,649 European-ancestry individuals identifies 463 signals in 346 loci, roughly one-third sexually dimorphic and mostly stronger in women.
Verneri Anttila, Brendan K Bulik-Sullivan, Hilary K. Finucane…·Nicholas A. Furlotte
Genetic correlations across 25 brain disorders (215,683 cases) reveal broad psychiatric common-variant sharing, largely distinct neurological disorders, and migraine as the only significant cross-category link.
eQTLGen, Naomi R. Wray, 23andMe…·Niamh Mullins
Genome-wide association meta-analysis of 130,664 major depression cases and 330,470 controls identifies 44 independent risk loci enriched in cortical neurons, conserved mammalian regions, splicing networks, and antidepressant targets.
Iain Mathieson, Songül Alpaslan-Roodenberg, Cosimo Posth…·Cristian Virag
Ancient DNA from 223 people (12,000-500 BCE) reveals a west-east hunter-gatherer cline, largely unadmixed farmers, Caucasus-shifted Aegean farmers, and Balkan steppe ancestry almost 2,000 years early.
Clare Bycroft, Colin Freeman, Desislava Petkova…·Jonathan Marchini
Quality-controlled genotypes for 488,377 UK Biobank participants at 805,426 markers, imputed to ~96 million variants, plus ancestry PCs, kinship (30.3% have close relatives enrolled) and HLA calls.
Erin Bakshis Ware, Lauren Schmitz, Jessica D. Faul…·Sharon LR Kardia
Polygenic scores built 434 ways in Health and Retirement Study (HRS) participants varied widely in variance explained and inter-score correlation; European-derived weights underperformed in non-Hispanic Blacks.
yHaplo walks the Y-chromosome tree with an error-tolerant breadth-first search, labelling the 1,244 1000 Genomes males in 20 seconds and matching every gold-standard call.