Mark J. Adams

This paper identifies 58 genome-wide significant loci for major anxiety disorders using a large meta-analysis and highlights GABAergic signaling as a potential mechanism.

This study identifies 52 genetic variants associated with adolescent-onset depression through a large GWAS, revealing age-specific mechanisms and potential drug targets.

The paper identifies novel CNV loci and dose-dependent gene effects across six psychiatric disorders using genome-wide analysis.

The paper identifies shared and divergent genetic mechanisms across psychiatric disorders using gene-set burden analysis of copy number variants.

This study conducts a genome-wide association analysis of generalised anxiety symptom severity, identifying 80 significant variants and showing genetic correlations with other mental and physical health traits.

The paper describes a large DNA methylation dataset from the Generation Scotland cohort, providing methylation profiles and associated phenotypes for research purposes.

The paper evaluates the accuracy of polygenic risk scores for MDD in African ancestry UK Biobank participants using European and African GWAS data, finding lower predictive power from European-derived PRS.

This study identifies genetic subtypes of major depressive symptoms by analyzing data from clinical and community cohorts, finding distinct factors for appetite/weight symptoms and missing data patterns.

The paper identifies parent-of-origin effects on the methylome linked to aging rates by analyzing CpG methylation in a large family cohort.

This study characterizes MDD subgroups based on weight and sleep changes, finding distinct clinical and genetic profiles, including novel associations with epilepsy and immunometabolic genes.

This study calculates pathway-based polygenic risk scores for schizophrenia using gene-sets related to synaptic function and histone modification, and finds associations with neuroimaging and clinical traits in UK Biobank.

This paper conducts a multi-ancestry GWAS meta-analysis of suicide attempt, identifying 12 genome-wide significant loci and finding shared genetic risks with ADHD, smoking, and risk tolerance.

This study identifies four genetic factors underlying 11 psychiatric disorders and finds limited evidence for a single dimension of genetic risk across them.

A genome-wide association study of 69,369 schizophrenia cases and 236,642 controls identifies 270 risk loci, prioritizes 130 genes, and links common and rare risk variants to neuronal synaptic biology.

This study examines genome-by-trauma interaction effects on depression using whole genome data and finds significant variance explained by these interactions, particularly in males.

This study identifies modifiable parent-of-origin effects on DNA methylation by analyzing genetic and environmental factors in a large cohort.

This paper develops a transcriptome-based polygenic risk score (T-PRS) linking depression-related cortical gene expression changes to brain morphology and symptom severity in MDD.

This study performs a meta-analysis of GWAS on self-reported headache and migraine, identifying four new risk loci for headaches using 397,385 samples.

This study investigates the relationship between early life stressors and adult mental health through methylome-wide association studies, finding no evidence of methylome mediation but linking birth date to blood cell type composition.

This study identifies genetic loci associated with suicide attempts and shows shared genetic architecture with psychiatric disorders and non-psychiatric risk factors.

This study conducts a sex-stratified genome-wide association study of multisite chronic pain in UK Biobank, identifying sex-specific genetic loci and highlighting sex differences in chronic pain mechanisms.

This paper identifies DNA methylation sites associated with aggression through a meta-analysis of epigenome-wide studies across different age groups and tissues.

This study identifies traits associated with polygenic risk for depression using UK Biobank data and finds causal links between depression risk and brain structure, as well as environmental interactions.

This study identifies 3 genetic loci associated with neck or shoulder pain using UK Biobank data, with partial replication in Generation Scotland.

The paper identifies a conserved enhancer variant in the GAL gene associated with male anxiety and ethanol intake using human data and CRISPR mouse models.

The paper associates eQTL-derived gene expression scores with white matter microstructure in UK Biobank, identifying 8 significant genetic proxies linked to structural connectivity traits.

The paper examines genetic and shared couple environmental factors influencing smoking and alcohol use in the UK population using family and couple data.

This study identifies 11 novel SNPs associated with chronic pain and MDD using cFDR analysis, finding pleiotropy involving LRFN5 and other genes.

This paper shows that GWAS using minimal phenotyping for depression identifies non-specific genetic factors shared with other psychiatric conditions, not specific to major depressive disorder.

This study identifies 73 genome-wide significant loci for mood disorders, revealing shared and distinct genetic factors between major depressive disorder and bipolar disorder.