Discover, rate, and discuss biology preprints.

The paper shows that mutation accumulation studies in microbes may have selection bias due to reporting practices and provides a model to estimate selection and mutation spectrum.

This paper introduces a method to detect meiotic drivers in D. melanogaster by analyzing embryonic marker transmission.

The paper assesses regulatory activity of cortical structure-associated variants using MPRA in human neural progenitor cells, identifying 918 variants with regulatory potential and showing condition-dependent effects.

The paper uses ddRADSeq to analyze genetic structure in southern flounder over multiple years, finding significant differentiation between regions and temporal variability within estuaries.

The paper quantifies the contribution of structural variants to complex trait heritability using MiXeRSV, finding SVs explain up to 32% of heritability in some traits.

This paper evaluates soda-baited RNAi yeast as an effective, long-lasting mosquito control method, showing high mortality rates across multiple species and environments.

This paper introduces an alignment-free method for microhaplotype genotyping using GT-seq data, enabling robust inference of diploid genotypes from high-depth amplicon sequencing.

The paper identifies cryptic diversity in Astyanax species from the Magdalena basin using molecular and morphometric analyses, revealing two distinct genetic groups and morphospecies.

This study identifies genetic loci associated with drought-related traits in bread wheat using genome-wide association analysis.

This study identifies fast and slow gene expression changes in human blood after acute social stress, revealing distinct immune cell-related transcriptional responses and potential molecular mechanisms linking stress to psychiatric disorders.

The paper investigates whether diversity at the HYP1 locus in potato cyst nematodes arises from developmental editing or sequencing errors, concluding it is due to evolutionary forces.

This paper evaluates sampling methods for protein language models, showing that multi-mutant strategies outperform single-mutant approaches in capturing epistatic interactions for functional protein design.

The paper identifies susceptibility genes for septoria nodorum blotch in U.S. hard winter wheat using genetic markers and association studies.

SPLENDID improves polygenic risk prediction across diverse populations by incorporating continuous genetic ancestry without requiring discrete ancestry labels.

The paper investigates how POT1 mutations affect telomere inheritance and cancer risk by analyzing telomere length in families with POT1 mutations.

The paper investigates whether Cenp-C genes duplicated alongside Cid genes in the montium group of Drosophila, finding that most species retain only one Cenp-C gene despite multiple syntenic loci.

The paper introduces a framework to determine cis or trans regulation contributions to gene expression differences between strains or species and applies it to yeast, human-chimpanzee hybrid, and mouse data.

The paper introduces a missense mouse model of Kabuki syndrome with intact KMT2D function, showing similar phenotypes to loss-of-function models but without altered adult neurogenesis and with novel kidney agenesis.

EWF 2.0 is an exact simulation algorithm for Wright-Fisher diffusions with time-varying demography, validated through distributional tests and maintaining computational efficiency.