Dat Nguyen

The paper uses sequence-to-function models to show that long-range regulatory information in vertebrate genomes stops being shared before local sequence information, with a phylogenetic boundary around 320-435 Mya.

The paper quantifies the contribution of structural variants to complex trait heritability using MiXeRSV, finding SVs explain up to 32% of heritability in some traits.

The paper introduces nf-RASQUAL, a Nextflow pipeline for molQTL mapping in small datasets, applied to Atlantic salmon to identify expression and chromatin accessibility QTLs.

This paper develops a deep learning framework to predict the regulatory impact of non-coding variants in farmed animals using chromatin data, improving genomic prediction for livestock and aquaculture.

This study compares imputation accuracy and polygenic score performance between genotyping arrays and low coverage whole-genome sequencing across diverse populations, finding that low coverage sequencing performs competitively and better in underrepresented groups.

The paper develops an integrative framework for circRNA QTL discovery, improving detection rates and identifying potential immune disease regulators in human T cells.

LmTag improves tag SNP selection by prioritizing functional SNPs while enhancing imputation accuracy for population-specific genotyping arrays.

This paper evaluates imputation and polygenic score performance of 23 human genotyping arrays across 6 ancestry groups using public and in-house datasets, finding that array selection significantly impacts results.