Author

Julie Michelle Grosse-Sommer

University of EdinburghORCID 0000-0001-5060-4601Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Jarrod D. HadfieldiD· 2 shared Dhobasheni Newman· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

2 top collaborators · 1 mutual co-author link

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2 shared papersGenetics

Jarrod D. HadfieldORCID

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2 papers

Recent·Most cited

GeneticsGeneticsPeer-reviewedSep 25, 2026

Selection bias in microbial mutation accumulation studies and the impact of colony growth

Julie Michelle Grosse-Sommer, Jarrod D. Hadfield

The paper shows that mutation accumulation studies in microbes may have selection bias due to reporting practices and provides a model to estimate selection and mutation spectrum.

DOI 10.1093/genetics/iyag263

E. coliDNA methylation

𝕏 PostBluesky

Evolutionary BiologybioRxivPreprintAug 25, 2026

Fitness effects of new mutations are small and heavily confounded with non-genetic sources of variation in Escherichia coli

Julie Michelle Grosse-Sommer, Dhobasheni Newman, Jarrod D. Hadfield

This study estimates the fitness effects of new mutations in E. coli and finds they are small and heavily confounded with non-genetic variation.

DOI 10.64898/2026.08.23.746582

E. coliexperimental assay

𝕏 PostBluesky