Robert Lu

The paper investigates how POT1 mutations affect telomere inheritance and cancer risk by analyzing telomere length in families with POT1 mutations.

The paper identifies principles governing BRCA2 reversion mutations that confer resistance to PARP inhibitors using CRISPR editing and an isogenic cell system.

This study identifies domain 36 of tropoelastin as the site of transient interaction with heparin, which nucleates and promotes coacervation through multivalent binding.

This study uses deep scanning mutagenesis to analyze POT1 mutations in human stem cells, revealing that some cancer-associated variants drive telomere elongation and oncogenesis independently of telomere replication.