Discover, rate, and discuss biology preprints.

The paper introduces a hypothesis test to detect linkage disequilibrium adjusted for population structure in human datasets.

The paper identifies 22,377 de novo genes in 21 Brassicaceae genomes, showing variation in birth/death rates and factors influencing their turnover.

The paper generates a chromosome-level reference genome for Crassostrea virginica using PacBio HiFi, Illumina, and Hi-C data, achieving high completeness and reduced duplication.

The paper presents a chromosome-level genome of a type B avocado cultivar, identifies structural variations at flowering-type loci, and predicts the flowering type of a West Indian accession.

The paper presents a chromosome-level genome and caste transcriptomes for Belonogaster juncea, revealing genomic diversity and caste-specific gene expression differences.

This paper benchmarks the AlphaGenome Variant Impact score against SpliceAI on post-release ClinVar classifications and experimental splicing assays, finding AVI performs well but not outperforms splicing predictors on AUROC.

The paper introduces OPTIMuS PRIME-Del, a CRISPR-based method for multiplexed, precise deletion of cis-regulatory elements, validated through molecular tagging and scRNA-seq analysis.

The paper presents a near-complete genome assembly of the African turquoise killifish and evaluates how TR detection programs and TE workflows affect TE expression profiling.

The paper systematically perturbs the human genome to reveal a relational network of genomic dependencies, uncovering 'relons' that reflect functional and evolutionary constraints.

The paper introduces distributed AI agents to analyze large-scale biological datasets, demonstrating their ability to rapidly extract insights and predict outcomes across a Perturb-seq atlas.

The paper shows rapid evolutionary responses to climate change in maritime pine despite widespread adaptive lag, using genomic data and simulations.

The paper presents a telomere-to-telomere genome assembly of the naked mole-rat and compares it with a related species to identify gene losses and duplications associated with unique traits.

The paper identifies a compact regulatory logic governing fibroblast plasticity in fibrosis by analyzing enhancer repression and gene perturbations across multiple tissues.

The paper identifies ZBTB7B as a master regulator of salivary acinar cell function through transcriptional and regulatory analyses in human and mouse salivary glands.

This study presents a chromosome-level genome assembly of Falcataria falcata to investigate ancient polyploidy and duplicate gene evolution in Fabaceae, finding evidence for both ancestral and lineage-specific WGD events.

This study characterizes gene-product relationships in wheat gliadin loci to develop reduced immunogenicity wheat lines through genetic and molecular analyses.

This study benchmarks multiple sequencing-based spatial transcriptomics platforms across tissue types and preservation methods to evaluate their performance and establish standardized metrics for future research.

This study uses nanopore sequencing to determine the replication timing programme of Plasmodium falciparum and links it to DNA breaking and replication fork stalling.

This paper introduces a method to estimate self-fertilization rates using diploid genotype spectra from population genomic data.

The paper compares chromosome-scale genomes of two B. caapi ethnovarieties to identify genomic features associated with ethnovariety differentiation.