Dustin Sokolowski

Decoding the naked mole-rat genome, telomere to telomere

The paper presents a telomere-to-telomere genome assembly of the naked mole-rat and compares it with a related species to identify gene losses and duplications associated with unique traits.

In-Depth Immune Profiling Reveals Cell-Type, Sex and Infection-Stage Dependent Differences for Tuberculosis Control

This study profiles the immune environment in male and female mice following TB infection and vaccination, identifying sex-specific immune markers and known protective responses.

High Dimensional Immune Profiling Reveals CD39 as a Correlate of Tuberculosis Disease Severity

This study uses high-dimensional immune profiling to identify CD39 as a correlate of tuberculosis disease severity and shows its potential as a therapeutic target.

Methylphenidate exposure alters brain gene expression and induces transgenerational DNA methylation changes in Poecilia reticulata guppies

An updated reference genome sequence and annotation reveals gene losses and gains underlying naked mole-rat biology

The paper presents an updated reference genome for the naked mole-rat, identifying gene losses and gains linked to its unique physiological traits.

Age, sex, and cell type-resolved hypothalamic gene expression across the pubertal transition in mice

The paper analyzes hypothalamic gene expression in mice across puberty, identifying age- and sex-specific changes and their association with pubertal regulation.

Differential Expression Enrichment Tool (DEET): an interactive atlas of human differential gene expression

The paper develops DEET, a tool that reanalyzes differential gene expression data from multiple studies to help users compare their gene lists with existing results.

Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland

This study profiles gene and miRNA expression in mouse pituitaries across postnatal ages to identify sex-biased gene regulation and cell-type proportion differences during development.

Single-cell mapper (scMappR): using scRNA-seq to infer cell-type specificities of differentially expressed genes

scMappR assigns cell-type specificity scores to bulk RNA-seq DEGs using scRNA-seq data and deconvolution methods, showing accurate assignment in kidney regeneration analysis.

recount-brain: a curated repository of human brain RNA-seq datasets metadata

The paper curates a database of human brain RNA-seq metadata to improve reproducibility and analysis of gene expression data.