Gabriel Balmus

The paper presents a telomere-to-telomere genome assembly of the naked mole-rat and compares it with a related species to identify gene losses and duplications associated with unique traits.

This study uses prime editing to identify and characterize MutSβ inhibitors that reduce (CAG)n repeat expansion.

The paper develops URSA, a method to quantify DNA repair activity at the CAG repeat tract in HD, showing it correlates with somatic instability and can be measured rapidly in blood cells.

This study identifies USP7 as a stabilizer of FAN1, showing its role in DNA crosslink repair and suppression of CAG repeat expansion in Huntington's disease.

This paper introduces RECODR, a computational pipeline that tracks transcriptome changes in cancer development and treatment to predict resistance mechanisms and design effective therapies.

This study shows that ecDNA mis-segregation leads to micronuclei formation, reduced oncogene transcription, and improved patient survival in neuroblastoma.

The paper presents an updated reference genome for the naked mole-rat, identifying gene losses and gains linked to its unique physiological traits.