Discover, rate, and discuss biology preprints.

This study uses TRAP-seq to analyze the translatome of sensory satellite glial cells in a chronic pelvic pain mouse model, revealing sex-specific changes in mitochondrial and vesicular gene translation.

The paper examines how daily light exposure differs between extreme chronotypes and finds that these differences persist even when aligned to habitual sleep timing, with notable variations in exposure timing relative to sleep patterns.

This study shows that deleting Stim1/Stim2 in microglia reduces calcium signaling but leads to larger infarct sizes after ischemic stroke, suggesting CRAC signaling protects brain tissue.

This study identifies the CAV3-NCX1 axis as a mediator of ultrasound-induced inhibition of pathological brain hyperactivity, showing its role in suppressing hyperactive neurons and astrocytes.

The paper proposes a variational principle linking stimulus statistics to neural geometry and demonstrates its prediction of Bayesian-like behavior in recurrent neural networks.

This paper shows that mitochondrial dysfunction triggers a translational stress response via GCN2 kinase, leading to diabetic pain, and demonstrates interventions to block this pathway.

This study shows that a sensory reference for vocal learning is gated through the basal ganglia in songbirds, with HVC providing a temporally aligned tutor signal to Area X.

The paper compares how direction selectivity develops in two visual processing regions of Xenopus tadpoles, finding distinct developmental trajectories in tectal and tegmental neurons.

The paper examines how structure-function coupling in the brain varies across cognitive states using diffusion and functional MRI data from two cohorts.

This study shows that the Xist locus, known for XCI in females, has age- and domain-specific effects on male metabolism and cognition despite minimal expression.

This study simulates neural degradation in a computational model of the visual stream to show that dedifferentiation in aging can result from peripheral degradation rather than local changes.

The paper uses peptide-centric proteomics to identify molecular subtypes in sporadic Alzheimer's disease, revealing distinct phenotypes in specific brain regions.

This study identifies cell-type-specific proteomic changes in Huntington's disease mice, showing early synaptic protein downregulation in neurons and reduced neuronal support in glia as disease progresses.

This paper uses single-nucleus RNA-seq to map transcriptional changes in 5xFAD mouse brains, identifying VIP interneurons as the most vulnerable and showing rolipram's preferential rescue effect through Pde7b/CREB1 signaling.

This study investigates whether animacy categorisation training reduces animal bias in neural representations, finding limited neural reorganisation despite improved task performance.

TRACE reconstructs disease trajectories and infers subtypes and stages from sparse, cross-sectional biomarker data, showing effectiveness in neurodegenerative disease datasets.

The paper shows that oscillatory entrainment, not Bayesian learning, guides temporal prediction in non-deterministic environments with intermediate temporal jitter.

This study shows that neuronal Aralar deficiency causes ASD-like social behavior deficits through dopaminergic and redox dysfunction, which are reversed by β-hydroxybutyrate treatment.

This study combines non-linear and spectral heart rate variability metrics to differentiate between alcohol drinking and compulsive drinking in rats, finding sex-specific patterns related to consumption levels.

This study develops a task to measure both intrinsic and extrinsic motivation and finds that drugs affect these motivations differently, highlighting pharmacological divergence.