Author

Petr Tvrdík

University of Virginia Health SystemORCID 0000-0002-8750-9672Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Assay:imaging· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:spatial domain detection· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Khadijeh Alsadat SharifiiD· 3 shared Richard J. PriceiD· 3 shared Delaney G. FisheriD· 2 shared G. Wilson MilleriD· 2 shared M. Yashar S. KalaniiD· 2 shared Aminata P. CoulibalyiD· 1 shared Catherine M. GorickiD· 1 shared Claire Huchthausen· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersNeuroscience

Khadijeh Alsadat SharifiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Focused Ultrasound Augments the Delivery and Penetration of Model Therapeutics into Cerebral Cavernous Malformations

Delaney G. Fisher, Matthew R. Hoch, Catherine M. Gorick, Claire Huchthausen, Victoria R. Breza, Khadijeh Alsadat Sharifi, Petr Tvrdík, G. Wilson Miller, Richard J. Price

This study evaluates how focused ultrasound enhances drug delivery into cerebral cavernous malformations using contrast agents in a mouse model.

Journal of Controlled Release · Aug 28, 2024Peer-reviewedBioengineering

Dynamics of Adult Axin2 Cell Lineage Integration in Granule Neurons of the Dentate Gyrus

Khadijeh Alsadat Sharifi, Faraz Farzad, Sauson Soldozy, Richard J. Price, M. Yashar S. Kalani, Petr Tvrdík

The paper traces Axin2-positive cell lineage in adult hippocampal neurons, finding that Axin2 is expressed at multiple stages of differentiation and that integration of adult-born neurons can take longer than previously thought.

bioRxiv · Dec 9, 2023 · PreprintNeuroscience

Understanding Lesion Progression in a Chronic Model of Cerebral Cavernous Malformations through Combined MRI and Histology

Delaney G. Fisher, Khadijeh Alsadat Sharifi, Emine Zeynep Ulutas, Jeyan Sathia Kumar, M. Yashar S. Kalani, G. Wilson Miller, Richard J. Price, Petr Tvrdík

This study uses a chronic mouse model of CCM to analyze lesion progression with MRI and histology, revealing non-monotonous growth patterns and correlations between cell density and lesion stability.

bioRxiv · Nov 15, 2022 · PreprintNeuroscience

The neutrophil enzyme myeloperoxidase directly modulates neuronal response after subarachnoid hemorrhage, a sterile injury model

Aminata P. Coulibaly, Pınar Pezük, Paul Varghese, William Gartman, Danielle Triebwasser, Joshua A. Kulas, Lei Liu, Mariam Syed, Petr Tvrdík, Heather Anne Ferris, J. Javier Provencio

This study shows that myeloperoxidase from neutrophils in the meninges modulates neuronal function after subarachnoid hemorrhage, leading to cognitive deficits.

bioRxiv · Oct 19, 2019 · PreprintNeuroscience