Hongmin Wang

Homeostatic Activation of 26S Proteasomes by Protein Kinase A Protects against Cardiac and Neurobehavior Malfunction in Alzheimer's Disease Mice

This study shows that homeostatic activation of 26S proteasomes by PKA protects against brain and cardiac dysfunction in Alzheimer's disease mice.

Ser14-phosphorylated Rpn6 Limits Proteostasis Impairment and Pathology in Both Brain and Heart of Tauopathy Mice

This study shows that Ser14-phosphorylated Rpn6 protects against tauopathy-related brain and heart pathology by maintaining proteostasis.

Disrupting FOXO4 function confers neuroprotection against oxidative stress and ischemia-reperfusion-caused neuronal injury

This study shows that disrupting FOXO4 function reduces oxidative stress and neuronal injury in ischemia-reperfusion conditions, suggesting it as a therapeutic target for stroke.

Impaired proteasome induces mitochondrial DNA release to activate the cGAS-STING signaling pathway and cause necroptosis in mouse brain

This study shows that impaired proteasome in mouse brains leads to mitochondrial DNA release, activates the cGAS-STING pathway, and causes necroptosis, contributing to neuroinflammation and neurodegeneration.

Impaired 26S proteasome causes learning and memory deficiency and induces neuroinflammation mediated by NF-κB in mice

Peripherally expressed misfolded proteins remotely disrupt brain function and aggravate stroke-induced brain injury

This study shows that misfolded proteins in the heart can disrupt brain function and worsen stroke damage through prion-like mechanisms.