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This study identifies novel small-molecule inhibitors of SARS-CoV-2 main protease that suppress viral replication in human cells.

This study shows that deleting CerS6 reduces alcohol-induced fatty liver and improves glucose homeostasis in mice, and links CerS6 expression to ALD progression in humans.

This study develops CNNs to subtype and grade lung adenocarcinoma, achieving high accuracy and outperforming most pathologists in grading prediction.

This study identifies and analyzes lncRNAs in western honey bee larvae infected with Ascosphaera apis, revealing their regulatory roles in immune responses through transcriptome analysis and ceRNA network analysis.

This study analyzes big-data from a tertiary hospital to find that vitamin D deficiency is linked to worse outcomes in COVID-19 patients, including higher hospitalization rates and mortality.

The paper develops a gene-specific machine learning model to improve the prediction of KCNQ2 missense variant pathogenicity with high sensitivity and specificity.

The paper investigates the Allee effect in Hymenoscyphus fraxineus, showing that low host density limits inoculum production and disease development.

This paper introduces an improved qPCR method to quantify Fusarium crown rot infection in winter cereals, enabling better breeding for resistance and tolerance.

The paper shows surface glia are key in C9orf72-mediated ALS/FTD in Drosophila using genetic tools to mark glial subtypes.

This study identifies activin A's role in bone fracture repair by promoting a novel myofibroblastic progenitor cell population that drives chondrogenesis and osteogenesis.

This study shows that circadian genes are dysregulated in ASD patients' lymphoblastoid cells, linked to sleep phenotypes and altered gene networks.

This study shows S100A4 promotes smooth muscle cell motility in vitro but does not affect intimal thickening formation in a mouse carotid artery ligation model.

The paper analyzes HER2-positive breast cancer tumors at the single-cell level to identify phenotypic heterogeneity and its implications for response to HER2-targeted therapies.

The paper develops a single-cell MRD assay that detects residual leukemic clones with high sensitivity and reveals clonal architecture in AML.

This study compares dimethyl fumarate (DMF) and prednisone (PRED) in mdx mice, finding DMF improves muscle function and mitochondrial health while PRED causes side effects.

This study identifies VCAM-1 upregulation as a key marker of AKI-to-CKD transition, distinct from KIM-1, through mouse models and human single-cell transcriptomics.

The paper investigates the pathology of African swine fever in naturally infected wild boar, finding that variant IV causes a protracted disease course with lower viral load but more chronic lesions.

This study shows that PRR antagonism reduces hepatic steatosis and fibrosis in NAFLD models without affecting body weight or glucose levels.

This study examines how serum from chronic heat-not-burn cigarette smokers affects cardiac stromal cells, showing increased fibrosis and reduced paracrine support.