L. Zhong

Proteomic comparison of epidemic Australian Bordetella pertussis biofilm cells

This study compares proteomic differences between two clusters of Bordetella pertussis strains in biofilm conditions, identifying strain-specific protein expression variations linked to cluster dominance.

Exposure to titanium dioxide nanoparticles accelerates abnormal fat deposition through the mediation of the ROS via the AGE-RAGE signaling pathway in mice

This study shows that titanium dioxide nanoparticles induce fat deposition in mice by increasing ROS and activating the AGE-RAGE pathway, with NAC as a potential therapeutic.

Single Cell RNA Sequencing Reveals Emergent Notochord-Derived Cell Subpopulations in the Postnatal Nucleus Pulposus

This study uses single cell RNA sequencing to identify distinct subpopulations of notochord-derived nucleus pulposus cells in postnatal mice, revealing developmental stages and molecular signatures associated with extracellular matrix production.

Redistribution and activation of CD16brightCD56dim NK cell subset to fight against Omicron subvariant BA.2 after COVID-19 vaccination

This study shows that COVID-19 vaccination enhances the activation and redistribution of CD16brightCD56dim NK cells in Omicron BA.2-infected patients, improving clinical outcomes.

In depth characterization of an archaeal virus-host system reveals numerous virus exclusion mechanisms

The paper characterizes an archaeal virus-host system, revealing virus exclusion mechanisms and differences from bacterial systems.

Activin A promotes bone fracture repair and acts through a novel myofibroblastic cell population in callus

This study identifies activin A's role in bone fracture repair by promoting a novel myofibroblastic progenitor cell population that drives chondrogenesis and osteogenesis.

Global transmission of Salmonella enterica serovars associated with historical pork trade via Euramerica centralized sourcing

The paper analyzes Salmonella enterica isolates to show Euramerica's role in global Salmonella spread through pork trade and antimicrobial impact on its evolution.

CNTNAP4 signaling regulates osteosarcoma disease progression

This study shows that CNTNAP4 signaling promotes osteosarcoma progression, and its deletion reduces tumor growth, angiogenesis, and metastasis.

Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone

Integrating proteomic data with metabolic modelling provides insight into key pathways of Bordetella pertussis biofilms

This study integrates proteomic data with metabolic modeling to identify key metabolic pathway differences between biofilm and planktonic Bordetella pertussis cells.

The tRNA thiolation-mediated translational control is essential for plant immunity

This study identifies tRNA thiolation as essential for plant immunity by showing its role in regulating NPR1 translation and salicylic acid signaling in Arabidopsis.

Histone H3K4 methyltransferase DcATX1 promotes ethylene induced petal senescence in carnation

This study identifies DcATX1 as a histone methyltransferase that accelerates ethylene-induced petal senescence in carnation by regulating H3K4me3 levels and gene expression.

Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma

This study constructs a single-cell transcriptome atlas of multiple myeloma patients stratified by R-ISS, identifies PC subsets and immunotargets, and links them to prognosis and EBV infection.

Ageing impairs the airway epithelium defence response to SARS-CoV-2

This study investigates age-related differences in the nasal epithelium's response to SARS-CoV-2, finding that older adults have impaired host defense and lower viral load due to reduced host machinery expression.

A novel domain within the CIL regulates egress of IFITM3 from the Golgi and prevents its deleterious accumulation in this apparatus

This study identifies a novel domain in IFITM3 that regulates its egress from the Golgi and prevents membrane fusion inhibition and Golgi dysfunction.

Antifungal effects of alantolactone on Candida albicans: an in vitro study

This study shows alantolactone has antifungal effects against Candida albicans by inhibiting adhesion, biofilm formation, and cell membrane permeability.

Liver X Receptor; Controls Hepatic Stellate Cell Activation via Hedgehog Signaling

This study shows that LXRβ suppresses hepatic stellate cell activation via inhibition of Hedgehog signaling, offering a potential therapeutic target for liver fibrosis without causing liver steatosis.

Bone marrow adipogenic lineage precursors (MALPs) promote osteoclastogenesis in bone remodeling and pathologic bone loss

This study identifies marrow adipogenic lineage precursors (MALPs) as critical regulators of osteoclastogenesis through RANKL expression, showing their role in both normal bone remodeling and pathologic bone loss.

Significant functional differences despite morphological and molecular similarity in fully differentiated matched Conditionally Reprogrammed (CRC) and Feeder free dual SMAD inhibited expanded human nasal epithelial cells

The paper compares functional differences between two culture methods for nasal epithelial cells and finds significant variations in barrier integrity and CFTR-mediated chloride currents despite similar morphology and proteomics.

Novel antioxidant therapy with the immediate precursor to glutathione, γ-glutamylcysteine (GGC), ameliorates LPS-induced cellular stress in an in vitro cystic fibrosis model

This study shows that γ-glutamylcysteine (GGC) reduces LPS-induced oxidative stress and improves cell viability in a cystic fibrosis model.

Measuring site-specific glycosylation similarity between influenza A virus variants with statistical certainty

This paper quantifies glycosylation differences between influenza A virus strains to improve vaccine design by understanding how glycosylation affects antigenicity and immune escape.

Two-stage electro-mechanical coupling of a Kv channel in voltage-dependent activation

The paper identifies a two-stage electro-mechanical coupling mechanism in KV7.1 channels, where VSD transitions through intermediate and activated states to trigger pore opening.

Single cell transcriptomics identifies a unique adipocyte population that regulates bone marrow environment

The paper identifies a unique adipocyte population in bone marrow, MERAs, that regulate bone and vessel homeostasis through single-cell transcriptomics in mice.

Characterizing the Effects of Glutathione as an Immunoadjuvant in the Treatment of Tuberculosis

This study investigates the synergistic effects of NAC and first-line TB antibiotics on macrophage control of M. tb infection, finding enhanced immunomodulation and reduced bacterial viability.