R. L. Bowman

Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer

This study shows that hematopoietic Dnmt3a haploinsufficiency worsens colitis-associated colon cancer by promoting angiogenesis, which can be targeted with axitinib.

Single cell genotypic and phenotypic analysis of measurable residual disease in acute myeloid leukemia

The paper develops a single-cell MRD assay that detects residual leukemic clones with high sensitivity and reveals clonal architecture in AML.

Modeling clonal evolution and oncogenic dependency in vivo in the context of hematopoietic transformation

This study models clonal evolution and oncogenic dependency in hematopoietic transformation using reversible mutagenesis and allelic frameworks.

Jak2V617F Reversible Activation Shows an Essential Requirement for Jak2V617F in Myeloproliferative Neoplasms

This study shows that reversible activation of Jak2V617F in a mouse model demonstrates its essential role in myeloproliferative neoplasms and highlights the therapeutic potential of mutant-specific JAK2 inhibition.

Integrated Single-Cell Genotyping and Chromatin Accessibility Charts JAK2V617F Human Hematopoietic Differentiation

This paper develops GoT-ChA to link genotypes to chromatin accessibility in single cells, revealing JAK2V617F mutation-induced epigenetic changes in hematopoietic differentiation.

Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis

The paper shows that blocking CSF1R in brain metastases initially reduces tumor growth but is ineffective in established tumors due to compensatory macrophage activation, which is overcome by combining CSF1R and STAT5 inhibition.

Plasmacytoid dendritic cell expansion defines a distinct subset of RUNX1 mutated acute myeloid leukemia

This study identifies pDC-AML as a distinct AML subset with high RUNX1 mutations and pDC transcriptional features, suggesting CD123 targeting as a therapeutic strategy.

UVB mutagenesis differs in NRAS- and BRAF-mutant mouse models of melanoma

This study compares UVB mutagenesis effects in NRAS- and BRAF-mutant mouse melanoma models, finding BRAF-mutant tumors have more mutations and a stronger UVB mutational signature.

Single cell mutational profiling delineates clonal trajectories in myeloid malignancies

This study uses single-cell mutational profiling to analyze clonal trajectories in myeloid malignancies, revealing patterns of mutation acquisition and clonal complexity.

Stag1 and Stag2 regulate cell fate decisions in hematopoiesis through non-redundant topological control

The paper shows Stag2 loss in HSPCs impairs B-cell lineage commitment by reducing chromatin accessibility, while Stag1 cannot restore this function despite rescuing topological domains.