Author

R. M. Carr

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:flow cytometry· 1 Organism:mouse· 1

Frequent Co-Authors

G. Coltro· 2 shared M. Binder· 2 shared M. M. Patnaik· 2 shared A. A. Mangaonkar· 1 shared A. Al-Kali· 1 shared A. Buradkar· 1 shared A. Chiu· 1 shared A. Mangaonkar· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersImmunology

G. Coltro

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Ceramide synthase 6 (CerS6) promotes alcohol-induced fatty liver by promoting metabolic dysfunction and upregulating lipid droplet-associated proteins

S. Jeon, E. Scorletti, D. Buyco, C. Lin, Y. Saiman, J. Martin, R. Hooks, B. Ogretmen, J. Argemi, L. Melo, R. Bataller, R. M. Carr

This study shows that deleting CerS6 reduces alcohol-induced fatty liver and improves glucose homeostasis in mice, and links CerS6 expression to ALD progression in humans.

bioRxiv · Nov 3, 2022 · PreprintPathology

Indoleamine 2,3-dioxygenase-1 expressing aggregate bone marrow dendritic cell populations are associated with systemic T cell compartment changes in chronic myelomonocytic leukemia

A. Mangaonkar, K. K. Reichard, M. Binder, G. Coltro, T. L. Lasho, R. M. Carr, A. Chiu, V. Negron, M. Hefazi, T. Anagnostou, J. C. Villasboas, W. Gonsalves, N. Gangat, M. Shah, H. B. Alkhateeb, , M. M. Patnaik

This study examines the association between IDO1+ dendritic cell populations in CMML bone marrow and systemic T-cell changes, finding correlations with disease progression and immune suppression.

bioRxiv · May 14, 2020 · PreprintImmunology

RAS mutations drive proliferative chronic myelomonocytic leukemia via activation of a novel KMT2A-PLK1 axis

R. M. Carr, D. Vorobyev, T. Lasho, D. L. Marks, E. J. Tolosa, A. Vedder, L. Almada, A. Yurchenko, I. Padioleau, B. Alver, G. Coltro, M. Binder, S. L. Safgren, I. Horn, X. You, , M. M. Patnaik

This study identifies RAS mutations as drivers of proliferative CMML through a novel KMT2A-PLK1 axis, showing PLK1 inhibition can improve disease outcomes in patient-derived xenografts.

bioRxiv · Dec 23, 2019 · PreprintCancer Biology