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This study tracks the temporal changes in the tumor microenvironment after nanobody-based CAR-T therapy, revealing dynamic gene expression shifts and identifying potential therapeutic targets.

This study analyzes long-term esca disease incidence in Western Switzerland from 2001 to 2022, identifying water balance as a key climatic driver and observing a slight decreasing trend linked to drier conditions.

This study shows that neuronal hyperactivity selectively increases tau phosphorylation at S202/T205 in excitatory hippocampal neurons, which reduces GluA2 surface expression and may contribute to Alzheimer's disease pathology.

This study shows that Snai1 is not essential for somitogenesis, as its absence in the presomitic mesoderm does not disrupt segmentation clock activity or somite formation.

This study identifies disrupted multisensory processing in autistic children through EEG analysis, showing reduced theta-band connectivity and multisensory integration compared to controls.

The paper identifies a myosin filament cage in polarized epithelial cells that drives planar division and asymmetric cleavage, and shows its disruption leads to orthogonal division and multiple lumens.

The paper analyzes the genomic consequences of a severe bottleneck in Owens pupfish, finding reduced genetic diversity and a 17-fold contraction in effective population size, but low recent inbreeding due to population expansion.

This study identifies Janusein as a microtubule-associated protein that cooperates with EB proteins to enhance microtubule plus-end catastrophe.

This paper demonstrates agentic science on public infrastructure to ensure reproducibility by making all agent actions and workflows publicly accessible.

This study uses genetic biosensors to visualize calcium signaling dynamics in macrophages, revealing mechanosensitivity and the effects of Piezo1 channel ablation.

The paper describes a new crocodyliform species from the Santonian of Hungary and reassesses the taxonomy of European Cretaceous atoposaurids, finding potential polyphyly in Theriosuchus.

The paper uses interspecific hybrid embryos to identify EIF1A-family proteins as conserved nuclear regulators of zygotic genome activation across mammals.

The paper identifies age-dependent senescent endothelial cells in adipose tissue using snRNA-Seq and finds ion channel genes as predictive biomarkers.

The paper investigates somatic copy number variants (CNVs) in human neurons across development, finding that perinatal elimination of neurons with aberrant genomes reduces CNV prevalence and targets dosage-sensitive genes.

This study engineers T cells to respond to G-CSF instead of IL-2, enabling effective melanoma treatment without lymphodepletion or IL-2.

The paper adapts flow cytometry for field studies of immune cell seasonality in wild bats, revealing seasonal changes in immune cell populations.

This paper introduces an interactive server that combines a structure-aware GNN and ESMFold for bidirectional protein design, enabling users to analyze and validate design hypotheses without software installation.

This paper develops a sprayable antimicrobial film that prevents wound and medical device infections by forming a nanometric polyelectrolyte complex on surfaces.

This study shows that activating pyramidal tract neurons in the motor cortex reduces pathological dopaminergic motor responses in mice with Parkinson's-like symptoms.