Bian Liu

This study shows that neuronal hyperactivity selectively increases tau phosphorylation at S202/T205 in excitatory hippocampal neurons, which reduces GluA2 surface expression and may contribute to Alzheimer's disease pathology.

The paper develops sensitive FRET biosensors to visualize CaMKII activity dynamics in living cells and demonstrates their use in cultured and primary cells, including neurons and cardiomyocytes.

The paper uses a CaMKII activity reporter to study activation patterns in cardiac, skeletal muscle, and neurons, revealing differences in activation rates and subcellular localization.

This study shows that deletion of the proton-activated chloride channel in neurons leads to endosomal hyper-acidification, impairing AMPA receptor endocytosis and long-term depression.

This study shows SynGAP regulates synaptic plasticity and cognition through phase separation, not its catalytic activity.

This paper introduces ST-Cal-Light, a method to tag active neurons by converting somatic calcium signals into gene expression, enabling precise functional circuit analysis.

The paper develops DELTA, a method to measure brain-wide synaptic protein turnover at single-synapse resolution, revealing localized plasticity in hippocampal CA1 during learning.