Paul D. Robbins

The paper identifies age-dependent senescent endothelial cells in adipose tissue using snRNA-Seq and finds ion channel genes as predictive biomarkers.

This paper develops an AI-enabled platform to screen FDA-approved drugs for geroprotective effects, identifying 31 compounds that increase heat resistance in C. elegans and show anti-senescent activity in human cells.

This study shows that cellular senescence disrupts liver zonation and hepatocyte function with age by altering gene expression and cell signaling.

The paper identifies mitochondrial plaques in Alzheimer's disease by showing their presence in AD mouse models and human brains, linking them to mitophagy dysfunction and lysosomal impairment.

The paper analyzes transcriptomic changes in human fibroblasts under different senescence-inducing conditions, finding shared pathway-level responses and inducer-specific gene-level variations.

This study identifies lipid senolytics that kill senescent cells via ferroptosis, extending healthspan in mice by targeting ACSL4, LPCAT3, and ALOX15.

The paper examines p21Cip1 and p16Ink4a expression in senescent cells across tissues, revealing heterogeneity and tissue-specific SASP profiles.

This study presents a longitudinal assessment of age-related changes in Brown-Norway rat physiology and histopathology at 6, 17, and 27 months of age to provide healthspan parameters for aging research.

This study identifies fucoidans as senotherapeutics that enhance SIRT6-dependent DNA repair and reduce senescence in aged mice.

This study shows that fucoidan, a seaweed-derived polysaccharide, extends healthspan and lifespan in aged mice by activating SIRT6, which reduces LINE1 retrotransposon activity and epigenetic aging.

This study develops two novel flavonoid senolytics through phenotypic drug screening and design, showing enhanced senolytic activity and healthspan extension in a mouse model.

This study identifies miR-142-3p as a regulator of human longevity by modulating the insulin/IGF-1 signaling pathway in B-cells and mice.

The paper identifies a longevity-associated SMAD3 non-coding variant that impairs a cell-type specific enhancer, reducing inflammation and senescence in endothelial cells and improving healthspan in a mouse model.

The paper identifies a SIRT6 variant enriched in centenarians that improves genome stability through enhanced mADPr activity and interaction with Lamin A.