Neuronal Hyperactivity Induces Tau Phosphorylation Selectively in Excitatory Pyramidal Neurons Which Contributes to GluA2 Regulation
Manyi Nina Sun, Kevin Vaughey, Bian Liu, Haidan Guo, Richard L. Huganir, Meaghan Morris
This study shows that neuronal hyperactivity selectively increases tau phosphorylation at S202/T205 in excitatory hippocampal neurons, which reduces GluA2 surface expression and may contribute to Alzheimer's disease pathology.
bioRxiv · Oct 28, 2026 · PreprintNeuroscience