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This study shows that intrathecal Shikonin reduces bone cancer pain in rats by suppressing spinal IGF2-associated p38 MAPK signaling, improving pain-related behaviors and reducing inflammation.

This study identifies Langerhans cells as immune-derived amplifiers of cutaneous sensory signaling and identifies semaphorin 7A as a mediator of LC-induced itch potentiation.

This study identifies TilR, a MarR-family regulator in Klebsiella oxytoca, as a repressor of tilimycin biosynthesis and links it to metabolic and virulence-related gene expression.

The paper integrates association mapping and transcriptomics to identify candidate genes and molecular mechanisms associated with sugarcane resistance to smut.

The paper identifies a dynamic stem cell state marked by Panx3 that responds to environmental cues and enables regeneration in aged and osteoarthritic joints.

This study evaluates a M4-selective PAM in nonhuman primates, showing broad cognitive and motivational improvements without adverse side effects.

This paper introduces SSAF-T, a segmentation-free framework for cell-type inference in spatial transcriptomics that avoids cell segmentation and enables accurate cell-type-guided segmentation.

This study identifies extensive horizontal gene transfer in the fungus gnat Bradysia coprophila, showing these genes contribute to stress tolerance and ecological adaptation.

This study shows that a nanotherapy (rPS) that induces islet graft tolerance can be compromised by MRSA infection, but combining it with methylprednisolone improves survival.

This paper introduces scJDO2, a method to separate score and flow operators from single-cell time courses, evaluating their ability to identify unstable cells and bifurcations in hematopoiesis.

The paper clusters filopodia dynamics using functional data analysis to identify distinct temporal patterns linked to Notch signaling in fruit fly development.

The paper identifies genomic signatures of positive selection and relaxed constraints in Dysdera spiders with convergent dietary specialisation on woodlice.

DisCell identifies and separates spillover from niche responses in spatial transcriptomics data, confirming a previously reported finding about esophageal cancer cells.

The paper introduces a framework to quantify uncertainty in SPICE MRSI reconstructions using Laplace approximation and Hessian-vector products, validated with in vivo experiments.

This study uses proteomics to identify aging and Aβ-related molecular changes in mouse brains and finds they are conserved in human AD proteomes.

This paper introduces a non-iterative method to create molecular probability maps from single-molecule localization data, preserving positional likelihood without coordinate-based rendering.

This study traces the evolutionary histories of human cholinergic proteins across eukaryotes using phylogenomic analysis, revealing heterogeneous patterns and phylogenetic relationships.

This paper validates the redesigned homeRNA platform's robustness to remote study stresses, showing it maintains RNA quality under varied conditions and storage times.

This paper develops a KIR3DL2-directed CAR T-cell therapy for T-cell lymphomas, showing preclinical efficacy and safety in xenograft models.

This study links ER stress and impaired NAD biosynthesis via QPRT to reduced oocyte quality and shows that NMN supplementation improves oocyte function and early embryonic development.