Hosein Toosi

DisCell identifies and separates spillover from niche responses in spatial transcriptomics data, confirming a previously reported finding about esophageal cancer cells.

The paper uses multimodal single-cell profiling to show how puberty and chemotherapy affect pediatric ovarian tissue, identifying vulnerabilities and a potential biomarker.

CopyMix jointly infers cell clusters and copy number profiles from single-cell DNA sequencing data, avoiding clustering artifacts and parameter tuning.

The paper identifies heritable transcriptional diversity within cell types by studying clonal human lymphocytes and mouse brain cells, showing clone-specific chromatin accessibility leads to distinct gene expression.

Celloscope deconvolves cell types in spatial transcriptomics data using marker genes, outperforming existing methods and accurately identifying brain structures and immune infiltrates.

PhylEx reconstructs clonal structure by integrating bulk DNA-seq and scRNA-seq data, outperforming existing methods in clonal-tree reconstruction and mutation clustering.