William T. Clarke

A Framework for SPICE MRSI Reconstruction Posterior Uncertainty Quantification

The paper introduces a framework to quantify uncertainty in SPICE MRSI reconstructions using Laplace approximation and Hessian-vector products, validated with in vivo experiments.

The Impact of BOLD Induced Linewidth Modulation on Functional 1H MRS Analysis

This study evaluates bias in functional MRS analysis due to BOLD-induced linewidth modulation and recommends correction methods to improve accuracy.

Breathlessness catastrophising after COVID-19 involves both interoceptive and visceromotor connectivity

This study identifies two brain connectivity patterns associated with breathlessness catastrophising in post-COVID patients, suggesting both interoceptive and visceromotor pathway alterations.

Fully automated open-source analysis and interactive visualization of magnetic resonance spectroscopic imaging (MRSI) data in Osprey-MRSI

The paper introduces Osprey-MRSI, an open-source software package for fully automated MRSI data analysis and visualization, validated across multiple vendors and sites.

Longitudinal neurochemical profiling after experimental stroke using edited MR spectroscopy

This study uses longitudinal edited 1H-MRS to track GABA and glutamate changes after experimental stroke in rats, finding a transient GABA reduction without persistent inflammation or major behavioral impairment.

Age-related differences in neurometabolite concentrations during early infancy: A cross-sectional analysis of the HBCD Release 1.0

The paper analyzes age-related changes in neurometabolite concentrations in infants using 1H-MRS data from the HBCD study, finding significant increases in some metabolites and decreases in others.

Open-Source Framework for Measurement of the Gradient Impulse Response Function

The paper presents an open-source framework for measuring the Gradient Impulse Response Function (GIRF) in MRI, enabling reproducible and accessible scanner-specific GIRF characterization.

Ultrasound-mediated neuromodulator delivery reveals serotonergic control of context-dependent motivation in primates

This paper introduces ultrasound-mediated neuromodulator delivery to study serotonergic control of context-dependent motivation in primates, showing altered neural activity and reduced reward environment influence.

Non-invasive measurement of neurotransmitter-specific glucose metabolism in the human brain using proton-observed proton-edited 13C-MRS (POPE13C-MRS)

This paper introduces POPE13C-MRS, a method to non-invasively measure neurotransmitter-specific glucose metabolism in the human brain using standard MRI hardware, demonstrating its feasibility in mice and humans.

A hippocampal neuroimaging signature of neurovascular insulin signalling links metabolism to mood

The paper identifies a hippocampal metabolic signature linked to mood and insulin signalling in depression, showing conserved effects across humans and mice.

MR Spectroscopy without Water Suppression using the Gradient Impulse Response Function

This paper introduces a method to correct artefactual sidebands in non-water-suppressed MR spectroscopy using the Gradient Impulse Response Function, improving metabolite signal recovery.

Low-intensity focused ultrasound to human amygdala reveals a causal role in ambiguous emotion processing and alters local and network-level activity

This study uses low-intensity focused ultrasound to modulate human amygdala activity and finds it alters emotional processing and reaction times to ambiguous stimuli.

Noradrenaline causes a spread of association in the hippocampal cognitive map

This paper shows that noradrenaline causes a spread of association in the hippocampal cognitive map, leading to overgeneralisation errors and predicted by physiological markers.

Diffusion MRS tracks distinct trajectories of neuronal development in the cerebellum and thalamus of rat neonates.

This study uses diffusion-weighted MRS to track cell-specific developmental trajectories in the cerebellum and thalamus of rat neonates, revealing age-related changes in metabolite diffusion properties.

Correlated and Anticorrelated Binocular Disparity Modulate GABA+ and Glutamate/glutamine Concentrations in the Human Visual Cortex

This study examines how GABA+ and Glx concentrations in the human visual cortex change with correlated and anticorrelated binocular disparity, suggesting roles for excitation and inhibition in disparity selectivity.

Baclofen, a GABAB receptor agonist, impairs motor learning in healthy people and changes inhibitory dynamics in motor areas

This study shows baclofen, a GABAB receptor agonist, impairs motor learning and reduces expected decreases in GABA levels during motor learning.

7 Tesla MRS estimates of GABA concentration relate to physiological measures of tonic inhibition in the human motor cortex

The paper uses 7 Tesla MRS and TMS-hdEEG to show that MRS-GABA correlates with physiological measures of tonic inhibition in the human motor cortex.

Universal Dynamic Fitting of Magnetic Resonance Spectroscopy

The paper introduces a universal dynamic MRS toolbox that simultaneously fits dynamic spectra, reducing parameter uncertainty and replicating prior studies.

A 7T interleaved fMRS and fMRI study on visual contrast dependency in the human brain.

This study uses interleaved fMRS and fMRI to examine how visual contrast affects neurometabolite levels and BOLD responses in the human brain, finding non-linear relationships and consistent glutamate increases.

Continuous automated analysis workflow for MRS studies

This paper introduces an automated MRS analysis workflow that reduces manual steps and integrates with neuroimaging standards, improving efficiency and scalability.

NIfTI-MRS: A standard format for magnetic resonance spectroscopic data

The paper introduces NIfTI-MRS, a standardized format for magnetic resonance spectroscopy data to improve sharing and integration across the MRS community.

Cerebellar GABA change during visuomotor adaptation relates to adaptation performance and cerebellar network connectivity: A Magnetic Resonance Spectroscopic Imaging study.

This study uses MRSI to show GABA changes in the cerebellum during visuomotor adaptation correlate with performance and network connectivity.

tDCS induced GABA change is associated with the simulated electric field in M1, an effect mediated by grey matter volume in the MRS voxel

This paper investigates how the electric field induced by tDCS in the motor cortex correlates with changes in GABA levels, finding that grey matter volume modulates this relationship.

Comparison of seven modelling algorithms for GABA-edited 1H-MRS

The paper compares seven algorithms for modelling GABA-edited 1H-MRS data from 222 subjects across 20 sites, finding moderate agreement and highlighting the need for standardized parameters.

Repeated unilateral handgrip contractions alter functional connectivity and improve contralateral limb response times: A neuroimaging study

This study shows that repeated unilateral handgrip contractions at 50% MVC improve contralateral hand response times and alter functional connectivity and neurochemical levels in sensorimotor areas.

A mechanism for hippocampal memory recall based on excitatory-inhibitory fluctuations in neocortex

The paper shows that hippocampal activity predicts excitatory-inhibitory fluctuations in visual cortex during memory recall.

Uncertainty in denoising of MRSI using low-rank methods

This paper assesses uncertainty reduction in MRSI denoising methods and proposes improved uncertainty estimation and rank threshold selection.

Multi-centre, multi-vendor 7 Tesla fMRI reproducibility of hand digit representation in the human somatosensory cortex

This study assesses the reproducibility of 7 Tesla fMRI hand digit representation across multiple sites and within sites, finding lower inter-site than intra-site reproducibility but overall feasibility for multi-site studies.

GABA relates to functional connectivity changes and retention in visuomotor adaptation

The paper investigates how GABA levels and functional connectivity in M1 and cerebellum relate to retention of visuomotor adaptation.

FSL-MRS: An end-to-end spectroscopy analysis package

FSL-MRS is an end-to-end magnetic resonance spectroscopy analysis toolbox that provides data processing, simulation, fitting, and visualization, validated on simulated and in vivo human datasets.