Identification and characterization of neoantigen-reactive CD8+ T cells following checkpoint blockade therapy in a pan-cancer setting
Keith Henry Moss, Ulla Kring Hansen, Vinicius Araújo Barbosa de Lima, Annie Borch, Esteban Sanchez Marquez, Anne-Mette Bjerregaard, Østrup Olga, Amalie Kai Bentzen, Andrea Marion Marquard, Mohammed kadivar, Inge Marie Svane, Ulrik Lassen, Sine Reker Hadrup
The paper detects neoantigen-reactive CD8+ T cells in tumor biopsies and peripheral blood post-checkpoint blockade therapy and identifies peptide hydrophobicity and treatment-induced phenotypes as factors influencing their response.
bioRxiv · Mar 17, 2024 · PreprintImmunology