Amalie Kai Bentzen

This study shows that Ag-Neo2/15 scaffolds expand antigen-specific T cells with enhanced cytotoxicity and reduced dysfunctionality compared to Ag-IL2/21 scaffolds.

ITRAP2 improves TCR-pMHC pairing accuracy by reducing noise and cross-contamination in single-cell data, outperforming existing methods on both in-house and public datasets.

The paper identifies HLA-specific depletion of CD8 T-cell responses to EBV and neuroantigens in MS patients, revealing immunophenotypic differences between MS and healthy donors.

The paper detects neoantigen-reactive CD8+ T cells in tumor biopsies and peripheral blood post-checkpoint blockade therapy and identifies peptide hydrophobicity and treatment-induced phenotypes as factors influencing their response.

A sequence-only convolutional network trained on T cell receptor (TCR)-peptide pairs for HLA-A*02:01 can single out TCRs that bind a target peptide among many non-binding ones.