Loss of PGC1α drives extracellular matrix remodelling in prostate cancer through CTHRC1
Alvaro Gonzalo-Paulano, Alice Macchia, Ariane Schaub-Clerigué, Benoit Louis Philippe Lectez, J Gardoki, Irati Lejona, U Armendariz-Martínez, Natalia Martín-Martín, Ianire Astobiza, P Alonso, Mikel Azkargorta, Félix Elortza, A M Aransay, Ivana Rondon‐Lorefice, I Mendizabal, , V Torrano
This study shows that loss of PGC1α in prostate cancer leads to ECM remodeling via CTHRC1, promoting tumor aggressiveness.
bioRxiv · May 8, 2026 · PreprintCancer Biology