Ianire Astobiza

eRREMS expands regulatory CpG coverage in reduced representation methylome sequencing

eRREMS improves CpG coverage in methylome sequencing by combining MspI and HaeIII digestion, outperforming RRBS and WGBS in capturing regulatory CpGs.

Loss of PGC1α drives extracellular matrix remodelling in prostate cancer through CTHRC1

This study shows that loss of PGC1α in prostate cancer leads to ECM remodeling via CTHRC1, promoting tumor aggressiveness.

Transcriptional network analysis of PTEN protein-deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

This study analyzes PTEN-deficient prostate tumors to reveal stromal reprogramming and senescent paracrine communication through transcriptional network analysis and single-cell RNA-Seq.

The transcriptional landscape of metastatic hormone-naive prostate cancer

This study characterizes the transcriptome of metastatic hormone-naive prostate cancer, identifying stroma remodelling and SOX11's role in metastasis.

Loss of UFMylation supports prostate cancer metastasis and rewires cell metabolism towards hexosamine biosynthesis

This study shows that loss of UFMylation promotes prostate cancer metastasis by reprogramming glucose metabolism towards hexosamine biosynthesis.

Secreted spermidine synthase reveals a paracrine role for PGC1a-induced growth suppression in prostate cancer

This study identifies spermidine synthase as a PGC1-regulated secreted protein that mediates paracrine tumor suppression in prostate cancer, highlighting a non-cell autonomous mechanism.

Transcription factor 19 is an androgen responsive gene that modulates vessel homeostasis and sustains metastatic prostate cancer

The paper identifies TCF19 as an androgen-responsive gene upregulated in metastatic prostate cancer, showing its role in vessel homeostasis and metastatic progression.