Mikel Azkargorta

ANKRD55 interacts with an IFT-B-like complex in microglia

The paper identifies ANKRD55 interacting with an IFT-B-like complex in microglia, suggesting a role in ciliary transport independent of ciliogenesis.

A generalizable normalization framework to decouple protocol and instrument effects: Application to high-sensitivity proteomics multicentric study (PME13)

This paper introduces a normalization framework to decouple protocol and instrument effects in multicenter proteomics studies, demonstrating its application to the PME13 dataset.

Oncostatin M cytokine promotes breast cancer progression by remodelling the extracellular matrix and activating integrin signalling in cancer cells

Loss of PGC1α drives extracellular matrix remodelling in prostate cancer through CTHRC1

This study shows that loss of PGC1α in prostate cancer leads to ECM remodeling via CTHRC1, promoting tumor aggressiveness.

Stiffness and Viscoelasticity of Adipose Tissue Decellularized Extracellular Matrix Hydrogels Influence Proliferation, Growth Pattern, Migration and Invasion of Breast Cancer Cells

This study shows that the stiffness and viscoelasticity of adipose tissue-derived hydrogels affect breast cancer cell proliferation, growth, migration, and invasion.

Vesicular Rps6 released by astrocytes regulate local translation and enhance synaptic markers in neurons

This study shows astrocytes regulate local protein synthesis in neurons by releasing extracellular vesicles containing Rps6, enhancing synaptic markers.

Astrocytic AMPK couples metabolic signals to hypothalamic circadian timing

This study shows astrocytic AMPK links metabolic signals to hypothalamic circadian timing by regulating phosphoproteome organization and behavior.

Molecular basis of Siglec-10 ligand recognition and antibody blockade

This study identifies key residues in Siglec-10 involved in ligand recognition and shows that antibody blockade can restore CAR-T cell cytotoxicity.

Loss of UFMylation supports prostate cancer metastasis and rewires cell metabolism towards hexosamine biosynthesis

This study shows that loss of UFMylation promotes prostate cancer metastasis by reprogramming glucose metabolism towards hexosamine biosynthesis.

Secreted spermidine synthase reveals a paracrine role for PGC1a-induced growth suppression in prostate cancer

This study identifies spermidine synthase as a PGC1-regulated secreted protein that mediates paracrine tumor suppression in prostate cancer, highlighting a non-cell autonomous mechanism.

Cullin-RING ligase BioE3 reveals molecular-glue-induced neosubstrates and rewiring of the endogenous Cereblon ubiquitome

The paper demonstrates that BioE3 can identify endogenous substrates and neosubstrates of Cullin-RING ligases, revealing changes in the ubiquitination landscape upon molecular glue treatment.

Trajectory analysis of hepatic stellate cell differentiation reveals metabolic regulation of cell commitment and fibrosis

This study maps the differentiation trajectory of iPSCs to hepatic stellate cells, identifying RORA as a key regulator of metabolic reprogramming and fibrosis.

Wnt binding to Coatomer proteins directs secretion on exosomes independently of palmitoylation

This study identifies the structural mechanism by which Wnt7a binds to exosomes for secretion, showing it is independent of palmitoylation and involves a dilysine motif interacting with COPB2.