Isogenic cortical organoids enable precision targeting of APP variant-specific pathways in Alzheimer's disease
Tobias Graß, Ilyas Mehmet Cosacak, Alban Ordureau, Feodor D. Price, Shrutika Kavali, A Caldarelli, Min N. Qiao, Badri Narayan Vardarajan, João A. Paulo, Michele Marass, Lee L. Rubin, Çağhan Kızıl, Natalia Rodríguez‐Muela
The paper uses isogenic cortical organoids to identify variant-specific pathogenic pathways in Alzheimer's disease and demonstrates targeted interventions that restore neuronal survival.
bioRxiv · Feb 20, 2026 · PreprintNeuroscience