Çağhan Kızıl

APOE-ϵ4-induced Fibronectin at the blood-brain barrier is a conserved pathological mediator of disrupted astrocyte-endothelia interaction in Alzheimer's disease

This paper identifies APOE-ϵ4-induced fibronectin accumulation at the blood-brain barrier as a key mediator of astrocyte-endothelial dysfunction in Alzheimer's disease, highlighting it as a potential therapeutic target.

Evolutionary origins and transcriptomic innovations of vertebrate Cajal-Retzius cells

This study investigates the evolutionary origins of Cajal-Retzius cells across vertebrates, finding they are conserved but gained specific transcriptomic features in amniotes.

Local genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry

Multi-omics characterization of vascular, neurodegenerative, and mixed neuropathology in the aging human brain

This study identifies molecular programs distinguishing vascular, neurodegenerative, and mixed pathology in aging human brains using proteomic and transcriptomic data.

Isogenic cortical organoids enable precision targeting of APP variant-specific pathways in Alzheimer's disease

The paper uses isogenic cortical organoids to identify variant-specific pathogenic pathways in Alzheimer's disease and demonstrates targeted interventions that restore neuronal survival.

Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer's Disease

This study identifies genetic covariance between early-onset Alzheimer's disease and lipid traits, highlighting three novel loci and potential causative genes.

NCBP2-AS2 is a mitochondrial microprotein, regulates energy metabolism and neurogenesis, and is downregulated in Alzheimer's disease

ABCA7-dependent Neuropeptide-Y signalling is a resilience mechanism required for synaptic integrity in Alzheimer's disease

This study identifies ABCA7-dependent neuropeptide Y signaling as a resilience mechanism critical for synaptic integrity and its disruption as a risk factor for Alzheimer's disease.

Ethanol exposure model in zebrafish causes phenotypic, behavioral and gene expression changes that mimic Fetal Alcohol Spectrum Disorders in human birth cohorts

Rare genetic variation in Fibronectin 1 (FN1) protects against APOEe4 in Alzheimer's disease

The paper identifies rare FN1 variants that protect APOEε4 carriers from Alzheimer's disease by modulating extracellular matrix deposition and gliosis.

Genetic admixture predictors of fetal alcohol spectrum disorders (FASD) in the South African Cape Coloured population

MU-BRAIN: MUltiethnic Brain Rna-seq for Alzheimer INitiative

The paper analyzes bulk RNA-seq data from diverse ethnic groups to identify differentially expressed genes and pathways in Alzheimer's Disease, highlighting cross-ethnic and ethnic-specific findings.

A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease

The paper identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease by characterizing their effects on human microglial subtypes in vitro and in a zebrafish model.

Foxj1 controls olfactory ciliogenesis and differentiation program of the olfactory sensory neurons

This study identifies Foxj1's role in regulating olfactory cilia formation and OSN differentiation in zebrafish and mice.

Extended genome-wide association study employing the African Genome Resources Panel identifies novel susceptibility loci for Alzheimers Disease in individuals of African ancestry

Temporal single-cell transcriptomic analysis of the sox1a:eGFP transgenic line identified the lateral floor plate progenitor cells as the origin of intraspinal serotonergic neurons

The paper uses single-cell RNA sequencing to identify lateral floor plate progenitor cells as the origin of intraspinal serotonergic neurons in zebrafish.

Ngfr suppresses Lcn2/Slc22a17 signaling, induces neurogenesis and reduces amyloid pathology in the hippocampus of APP/PS1dE9 mouse

The paper shows that Ngfr promotes neurogenesis and reduces amyloid pathology in AD mouse models by suppressing Lcn2/Slc22a17 signaling.

The Caribbean-Hispanic Alzheimer's Brain Transcriptome Reveals Ancestry-Specific Disease Mechanisms

The paper analyzes RNA-seq data from Caribbean-Hispanic Alzheimer's patients and controls to identify ancestry-specific gene expression patterns associated with disease.

Using conditional Generative Adversarial Networks (GAN) to generate de novo synthetic cell nuclei for training machine learning-based image segmentation

The paper uses GANs to generate synthetic cell nuclei and masks for training image segmentation models, demonstrating effectiveness with small datasets.

Diversity and Function of Motile Ciliated Cell Types within Ependymal Lineages of the Zebrafish Brain

The paper characterizes motile ciliated cells in zebrafish brain ventricles, showing their developmental origins, functional roles in CSF flow, and impact on ventricular morphology.

Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis

This study shows that habenular neurons develop sequentially, with their functional properties determined by their birthdate during development.

Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer’s model of adult zebrafish brain

Glia-neuron interactions underlie state transitions to generalized seizures

The paper investigates glia-neuron interactions during seizure transitions in zebrafish, finding that glial activity precedes and influences neuronal activity during seizures.

Single cell analyses of the effects of Amyloid-beta42 and Interleukin-4 on neural stem/progenitor cell plasticity in adult zebrafish brain

The paper uses single-cell transcriptomics to analyze how Amyloid-beta42 and Interleukin-4 affect neural stem/progenitor cell plasticity in adult zebrafish brain, identifying gene expression changes and cell-cell communication alterations.

Interleukin-4 restores neurogenic plasticity of the primary human neural stem cells through suppression of Kynurenic acid production upon Amyloid-β42 toxicity

This study shows that IL4 restores neurogenic plasticity of human NSCs by suppressing KAT2, which is upregulated in AD mouse models.

Re-arrangements in the cytoplasmic distribution of small RNAs following the maternal-to-zygotic transition in Drosophila embryos

The paper examines small RNA distribution in Drosophila embryos during the maternal-to-zygotic transition, revealing fraction-specific enrichment and dysregulation of miRNAs and transposon-derived small RNAs.

Instructive starPEG-Heparin biohybrid 3D cultures for modeling human neural stem cell plasticity, neurogenesis, and neurodegeneration

This paper introduces a 3D hydrogel culture system to model human neural stem cell plasticity, neurogenesis, and neurodegeneration, showing improved neuronal maturation and disease modeling.