Transcriptomic profiling of the middle temporal gyrus reveals differential glial/neuronal dysregulation across Alzheimer disease and aging.
Ignazio Stefano Piras, Anna Bonfitto, Serena Song, Arailym Aldabergenova, J Sloan, A Trejo, Juan Carlos Troncoso, Changiz Geula, Emily Joy Rogalski, Claudia H. Kawas, María M. Corrada, Thomas G. Beach, Geidy E. Serrano, Paul F. Worley, Carol Ann Barnes, Matthew J. Huentelman
This study uses bulk RNA-seq to analyze transcriptional changes in the middle temporal gyrus across Alzheimer's disease and aging, identifying distinct gene expression patterns and pathways associated with each condition.
bioRxiv · Oct 19, 2025 · PreprintGenomics