Thomas G. Beach

The paper examines sex differences in NMDA receptor density across Alzheimer's disease stages and finds sex-specific changes in mild cognitive impairment.

This study quantifies [18F]nifene binding to α4β2* nicotinic acetylcholine receptors in PD and CN brain tissues, finding increased binding in PD hippocampus and subiculum.

This study identifies APOE4/4-driven dysfunctional microglial states in Alzheimer's disease through multiomic analysis, revealing shifts toward terminal states with metabolic disruption and inflammatory signaling.

The paper fine-maps PD GWAS signals across cell types, revealing convergent glial-neuronal risk genes and a shared vesiculopathy network.

The paper identifies cis-acting genetic variants affecting enhancer function in Parkinson's Disease using multi-omics data and develops models to predict their regulatory impact.

This paper develops computational tools for allelic imbalance analysis using single-nucleus RNA-seq and demonstrates their application in a Parkinson's disease cohort.

This study links multidimensional MRI signatures to histological pathology in Alzheimer's disease, showing distinct diffusion-relaxation patterns associated with specific cellular and structural changes.

This study shows that FICD-mediated AMPylation contributes to Parkinson's disease by promoting α-synuclein aggregation and protein dyshomeostasis in dopaminergic neurons.

This study integrates long-read WGS and single-nucleus RNA-seq to identify structural variants affecting gene expression in Parkinson's disease with cell type resolution.

The paper identifies rare noncoding variants associated with Parkinson's disease using multi-omic data from over 3.3 million nuclei.

The paper quantifies the proteomic composition of amyloid plaques in AD models and human brains, revealing stage-dependent remodeling and conserved proteins across species.

This study shows that inhibiting Dyrk1a with the compound DYR533 reduces tau pathology, neuroinflammation, and amyloidosis in mouse models of neurodegenerative diseases.

This study examines the impact of vascular dementia on one-carbon metabolism by measuring protein expression in brain tissue, finding gender-specific differences in enzyme levels.

This study uses bulk RNA-seq to analyze transcriptional changes in the middle temporal gyrus across Alzheimer's disease and aging, identifying distinct gene expression patterns and pathways associated with each condition.

The paper identifies molecular programs coordinated with NPTX2 that distinguish cognitive resilience in AD pathology from non-pathological cognition and AD.

The paper uses long-read and single nucleus RNA-seq to identify novel SNCA transcript isoforms and their association with Parkinson's and Lewy body dementia.

This study examines how ischemic stroke affects levels of folate receptor and one-carbon metabolism enzymes in male and female brain tissue, finding sex-specific increases in these markers.

This study compares the transcriptomic landscapes of Alzheimer's disease, Dementia with Lewy bodies, and Parkinson's disease using single-nucleus RNA sequencing to identify shared and distinct molecular features.

This study identifies genetic risk factors for FTLD-TDP subtypes using whole-genome sequencing and meta-analysis across multiple cohorts.

This study shows that midkine reduces Aβ fibril formation and amyloid plaque development in Alzheimer's disease models.

This paper presents a multi-omics dataset from multi-ethnic Alzheimer's disease brain donors, including transcriptome, genome, and proteome data, to improve precision medicine for underrepresented populations.

This study shows that inhibiting IDO1 restores hippocampal glucose metabolism and rescues cognition in Alzheimer's disease models.

This study uses whole-genome sequencing to identify new genetic loci and structural variants associated with progressive supranuclear palsy, including novel signals in APOE and H1/H2 haplotype region variants.

The paper provides a public resource of single nucleus RNA sequencing data and multiscale networks from Alzheimer's disease and non-disease individuals, linking genetic variants to molecular features and revealing novel disease biology.

This study shows that TREM1 deficiency prevents age-related myeloid metabolic changes and cognitive decline in Alzheimer's disease models.

This study shows Src kinase is upregulated and phosphorylated in Alzheimer's disease, interacts with Tau, and may be a therapeutic target.

This study identifies circRNAs specific to dopamine and pyramidal neurons and links them to neuropsychiatric diseases.

The paper identifies the nucleus incertus (NI) in humans using neurochemical markers and shows its RLN3 expression and potential involvement in Alzheimer's disease pathology.

The paper links APOE4/4 genotype to lipid droplet accumulation in Alzheimer's microglia, showing its role in neurotoxicity through triglyceride synthesis and Tau phosphorylation.

This study identifies novel Alzheimer's disease risk loci by analyzing multi-ancestry GWAS data from diverse populations, highlighting the importance of including underrepresented groups in genetic research.