Geidy E. Serrano

Sex-divergent trajectories of hippocampal and cortical NMDA receptor density across the Alzheimer 's disease continuum

The paper examines sex differences in NMDA receptor density across Alzheimer's disease stages and finds sex-specific changes in mild cognitive impairment.

Increased Binding of Nifene, a PET Imaging Probe for α4β2* Nicotinic Acetylcholinergic Receptors in Hippocampus-Subiculum of Postmortem Human Parkinsons Disease Brain

This study quantifies [18F]nifene binding to α4β2* nicotinic acetylcholine receptors in PD and CN brain tissues, finding increased binding in PD hippocampus and subiculum.

APOE4 Drives Uniquely Dysfunctional Human Microglial States in Alzheimer's Disease

This study identifies APOE4/4-driven dysfunctional microglial states in Alzheimer's disease through multiomic analysis, revealing shifts toward terminal states with metabolic disruption and inflammatory signaling.

Single cell eQTL mapping reveals convergent glial-neuronal risk architecture in Parkinson's disease

The paper fine-maps PD GWAS signals across cell types, revealing convergent glial-neuronal risk genes and a shared vesiculopathy network.

Modeling cis-regulatory variation in human brain enhancers across a large Parkinson's Disease cohort

The paper identifies cis-acting genetic variants affecting enhancer function in Parkinson's Disease using multi-omics data and develops models to predict their regulatory impact.

Experimental and Computational Methods for Allelic Imbalance Analysis from Single-Nucleus RNA-seq Data

This paper develops computational tools for allelic imbalance analysis using single-nucleus RNA-seq and demonstrates their application in a Parkinson's disease cohort.

Separable multidimensional MRI signatures of cellular and structural pathology in Alzheimer's disease

This study links multidimensional MRI signatures to histological pathology in Alzheimer's disease, showing distinct diffusion-relaxation patterns associated with specific cellular and structural changes.

Aberrant FICD-mediated AMPylation drives α-Synuclein pathology and overall protein dyshomeostasis in dopaminergic neurons in Parkinson's disease

This study shows that FICD-mediated AMPylation contributes to Parkinson's disease by promoting α-synuclein aggregation and protein dyshomeostasis in dopaminergic neurons.

Integrating Long-Read Structural Variant Analysis with single-nucleus RNA-seq to Elucidate Gene Expression Effects in Disease

This study integrates long-read WGS and single-nucleus RNA-seq to identify structural variants affecting gene expression in Parkinson's disease with cell type resolution.

Massive-scale single-nucleus multi-omics identifies novel rare noncoding drivers of Parkinson's disease

The paper identifies rare noncoding variants associated with Parkinson's disease using multi-omic data from over 3.3 million nuclei.

Single Plaque Proteomics Reveals the Composition and Dynamics of the Amyloid Microenvironment in Alzheimer's Disease

The paper quantifies the proteomic composition of amyloid plaques in AD models and human brains, revealing stage-dependent remodeling and conserved proteins across species.

Dyrk1a inhibition with the Novel Compound DYR533: A Cross-Disease Therapeutic Strategy Targeting Amyloidosis, Tau Pathogenesis, and Neuroinflammation

This study shows that inhibiting Dyrk1a with the compound DYR533 reduces tau pathology, neuroinflammation, and amyloidosis in mouse models of neurodegenerative diseases.

Increased protein expression of methylenetetrahydrofolate reductase and cystathionine β-synthase in medial prefrontal cortical tissue of female vascular dementia patients

This study examines the impact of vascular dementia on one-carbon metabolism by measuring protein expression in brain tissue, finding gender-specific differences in enzyme levels.

Transcriptomic profiling of the middle temporal gyrus reveals differential glial/neuronal dysregulation across Alzheimer disease and aging.

This study uses bulk RNA-seq to analyze transcriptional changes in the middle temporal gyrus across Alzheimer's disease and aging, identifying distinct gene expression patterns and pathways associated with each condition.

NPTX2-Centered Cognitive Resilience Mechanisms in the Context of AD Pathology

The paper identifies molecular programs coordinated with NPTX2 that distinguish cognitive resilience in AD pathology from non-pathological cognition and AD.

Single cell transcriptomics reveals enrichment of aggregation-prone alpha-synuclein isoforms across synucleinopathies

The paper uses long-read and single nucleus RNA-seq to identify novel SNCA transcript isoforms and their association with Parkinson's and Lewy body dementia.

Ischemic stroke increases levels of the folate receptor and one-carbon enzymes in male and female brain tissue

This study examines how ischemic stroke affects levels of folate receptor and one-carbon metabolism enzymes in male and female brain tissue, finding sex-specific increases in these markers.

Comparative mapping of single-cell transcriptomic landscapes in neurodegenerative diseases

This study compares the transcriptomic landscapes of Alzheimer's disease, Dementia with Lewy bodies, and Parkinson's disease using single-nucleus RNA sequencing to identify shared and distinct molecular features.

Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing

This study identifies genetic risk factors for FTLD-TDP subtypes using whole-genome sequencing and meta-analysis across multiple cohorts.

Midkine Attenuates Aβ Fibril Assembly and Amyloid Plaque Formation

This study shows that midkine reduces Aβ fibril formation and amyloid plaque development in Alzheimer's disease models.

Large- Scale Deep Proteomic Analysis in Alzheimer's Disease Brain Regions Across Race and Ethnicity

The paper performs large-scale proteomic analysis of Alzheimer's disease brain regions across different racial and ethnic groups, identifying AD-related protein changes and APOE4 concordance with genotype.

Bridging the Gap: Multi-Omics Profiling of Brain Tissue in Alzheimer's Disease and Older Controls in Multi-Ethnic Populations

This paper presents a multi-omics dataset from multi-ethnic Alzheimer's disease brain donors, including transcriptome, genome, and proteome data, to improve precision medicine for underrepresented populations.

Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies

This study shows that inhibiting IDO1 restores hippocampal glucose metabolism and rescues cognition in Alzheimer's disease models.

Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy

This study uses whole-genome sequencing to identify new genetic loci and structural variants associated with progressive supranuclear palsy, including novel signals in APOE and H1/H2 haplotype region variants.

A public resource of single cell transcriptomes and multiscale networks from persons with and without Alzheimer's disease

The paper provides a public resource of single nucleus RNA sequencing data and multiscale networks from Alzheimer's disease and non-disease individuals, linking genetic variants to molecular features and revealing novel disease biology.

TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease models

This study shows that TREM1 deficiency prevents age-related myeloid metabolic changes and cognitive decline in Alzheimer's disease models.

Upregulation of the Proto-Oncogene Src Kinase in Alzheimer's Disease: From Molecular Interactions to Therapeutic Potential

This study shows Src kinase is upregulated and phosphorylated in Alzheimer's disease, interacts with Tau, and may be a therapeutic target.

Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease

This study identifies circRNAs specific to dopamine and pyramidal neurons and links them to neuropsychiatric diseases.

Unveiling a Novel Memory Center in Humans: Neurochemical Identification of the Nucleus Incertus, a Key Pontine Locus Implicated in Stress and Neuropathology

The paper identifies the nucleus incertus (NI) in humans using neurochemical markers and shows its RLN3 expression and potential involvement in Alzheimer's disease pathology.

APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia

The paper links APOE4/4 genotype to lipid droplet accumulation in Alzheimer's microglia, showing its role in neurotoxicity through triglyceride synthesis and Tau phosphorylation.