Linoleic acid metabolite, 13-S-hydroxyoctadecadienoic acid, suppresses cancer cell growth by inhibiting mTOR
Seung Ju Park, Hongmok Kwon, A Yeong Yang, Boah Lee, Haein Lee, Seung Eun Park, Seulgi Lee, Bernie Byunghoon Park, Yunhye Kim, Jin Wook Lee, Byung‐Chul Oh, Daniel Joseph Deredge, Patrick L. Wintrode, Mi‐Young Kim, Youngjoo Byun, Seyun Kim
The paper identifies 13-S-HODE as a tumor suppressive metabolite that inhibits mTOR by binding its ATP-binding domain, thereby suppressing cancer cell growth.
bioRxiv · Apr 2, 2025 · PreprintBiochemistry