Discovery of a Potent and Dual-Selective Bisubstrate Inhibitor for Protein Arginine Methyltransferase 4/5
A. A. Al-Hamashi, D. Chen, Y. Deng, G. Dong, R. Huang
The paper designs and synthesizes a potent dual-selective bisubstrate inhibitor for PRMT4/5, demonstrating high potency and selectivity with IC50 values of 2.8 nM and <1.5 nM.
bioRxiv · Sep 5, 2020Biochemistry