Author

A. A. Pioszak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Dickson· 1 shared J. A. Karim· 1 shared J. Lennon· 1 shared J. M. Booe· 1 shared K. M. Babin· 1 shared M. L. Warner· 1 shared P. H. Gordon· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 11 mutual co-author links

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1 shared paperBiochemistry

A. Dickson

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2 papers

Recent·Most cited

Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of theadrenomedullin2 G protein-coupled receptor

K. M. Babin, J. A. Karim, P. H. Gordon, J. Lennon, A. Dickson, A. A. Pioszak

The paper identifies AM2/IMD as a slow off-rate agonist for the AM2R receptor, showing prolonged cAMP signaling and defining the molecular mechanism of kinetic selectivity.

bioRxiv · Jan 13, 2023 · PreprintBiochemistry

Picomolar affinity antagonist and sustained signaling agonist peptide ligands for the adrenomedullin and calcitonin gene-related peptide receptors

J. M. Booe, M. L. Warner, A. A. Pioszak

The paper develops picomolar affinity antagonist and sustained signaling agonist peptides for AM and CGRP receptors, enhancing therapeutic potential through improved receptor binding and residence time.

bioRxiv · Feb 28, 2020Pharmacology & Toxicology