Discovery of Aminoglycosides as First in Class, Nanomolar Inhibitors of Heptosyltransferase I
J. A. Milicaj, B. A. Hassan, J. M. Cote, C. A. Ramirez-Mondragon, N. A. Jaunbocus, A. A. Rafalowski, K. R. Patel, C. D. Castro, R. Muthyala, Y. Y. Sham, E. A. Taylor
This study identifies aminoglycosides as the first nanomolar inhibitors of Heptosyltransferase I, with neomycin and kanamycin B being competitive inhibitors and tobramycin showing mixed inhibition.
bioRxiv · Oct 3, 2021Biochemistry