Author

E. A. Taylor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:protein folding & dynamics· 3 Assay:protein structure· 3 Approach:deep learning· 2 Approach:mechanistic / dynamical model· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1

Frequent Co-Authors

Y. Y. Sham· 4 shared B. A. Hassan· 3 shared J. Milicaj· 3 shared C. A. Ramirez-Mondragon· 2 shared A. A. Rafalowski· 1 shared C. D. Castro· 1 shared F. J. Tucci· 1 shared J. A. Milicaj· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersBiochemistry

Y. Y. Sham

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Author profile →

4 papers

Recent·Most cited

Kinetic Characterization and Computational Modeling of the Escherichia coli Heptosyltransferase II: Exploring the Role of Protein Dynamics in Catalysis for a GT-B Glycosyltransferase

B. A. Hassan, Z. A. Liu, J. Milicaj, M. S. Kim, M. Tyson, Y. Y. Sham, E. A. Taylor

This paper characterizes the kinetic and biophysical properties of Escherichia coli HepII, a GT-B glycosyltransferase, and develops a structural model to understand its catalytic mechanism and substrate interactions.

bioRxiv · Jun 13, 2022Biochemistry

Discovery of Aminoglycosides as First in Class, Nanomolar Inhibitors of Heptosyltransferase I

J. A. Milicaj, B. A. Hassan, J. M. Cote, C. A. Ramirez-Mondragon, N. A. Jaunbocus, A. A. Rafalowski, K. R. Patel, C. D. Castro, R. Muthyala, Y. Y. Sham, E. A. Taylor

This study identifies aminoglycosides as the first nanomolar inhibitors of Heptosyltransferase I, with neomycin and kanamycin B being competitive inhibitors and tobramycin showing mixed inhibition.

bioRxiv · Oct 3, 2021Biochemistry

Ligand Induced Conformational and Dynamical Changes in a GT-B Glycosyltransferase:Molecular Dynamic Simulations of Heptosyltransferase I Apo, Binary and Ternary Complexes

B. A. Hassan, J. Milicaj, Y. Y. Sham, E. A. Taylor

This study uses molecular dynamics simulations to analyze conformational and dynamical changes in HepI, revealing key interactions and motions critical for ligand binding and catalysis.

bioRxiv · Jun 16, 2021Biochemistry

Conserved conformational hierarchy across functionally divergent glycosyltransferases of the GT-B structural superfamily as determined from microsecond molecular dynamics

C. A. Ramirez-Mondragon, M. E. Nguyen, J. Milicaj, F. J. Tucci, E. A. Taylor, Y. Y. Sham

The paper uses molecular dynamics simulations to show that conformational hierarchy in GT-B glycosyltransferases is conserved, with specific residue motions affecting substrate binding without altering catalytic efficiency.

bioRxiv · Jul 2, 2020Biophysics