Author

C. A. Ramirez-Mondragon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

E. A. Taylor· 2 shared Y. Y. Sham· 2 shared A. A. Rafalowski· 1 shared B. A. Hassan· 1 shared C. D. Castro· 1 shared F. J. Tucci· 1 shared J. A. Milicaj· 1 shared J. M. Cote· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

E. A. Taylor

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Author profile →

2 papers

Recent·Most cited

Discovery of Aminoglycosides as First in Class, Nanomolar Inhibitors of Heptosyltransferase I

J. A. Milicaj, B. A. Hassan, J. M. Cote, C. A. Ramirez-Mondragon, N. A. Jaunbocus, A. A. Rafalowski, K. R. Patel, C. D. Castro, R. Muthyala, Y. Y. Sham, E. A. Taylor

This study identifies aminoglycosides as the first nanomolar inhibitors of Heptosyltransferase I, with neomycin and kanamycin B being competitive inhibitors and tobramycin showing mixed inhibition.

bioRxiv · Oct 3, 2021Biochemistry

Conserved conformational hierarchy across functionally divergent glycosyltransferases of the GT-B structural superfamily as determined from microsecond molecular dynamics

C. A. Ramirez-Mondragon, M. E. Nguyen, J. Milicaj, F. J. Tucci, E. A. Taylor, Y. Y. Sham

The paper uses molecular dynamics simulations to show that conformational hierarchy in GT-B glycosyltransferases is conserved, with specific residue motions affecting substrate binding without altering catalytic efficiency.

bioRxiv · Jul 2, 2020Biophysics