PINK1-parkin-mediated mitophagy generates stereotyped somatic mosaicism of the mitochondrial genome
A. Ahier, N. Cummins, C.-Y. Dai, J. Götz, S. Zuryn
The paper shows that PINK1 and parkin influence mitophagy, leading to tissue-specific differences in mitochondrial DNA mutation levels in C. elegans.
bioRxiv · Jun 12, 2020Cell Biology