Characterization of spike processing and entry mechanisms of seasonal human coronaviruses NL63, 229E and HKU1
S. N. Neerukonda, R. Vassell, S. Lusvarghi, S. Liu, A. Akue, M. Kukuruga, T. T. Wang, C. D. Weiss, W. Wang
This study investigates the entry mechanisms of seasonal human coronaviruses NL63, 229E, and HKU1 using pseudoviruses and cell lines expressing ACE2, APN, or TMPRSS2, revealing endocytosis as the entry route and specific protease and receptor requirements.
bioRxiv · Apr 12, 2024 · PreprintMicrobiology