Author

A. Alsamarah

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

W. M. Botello-Smith· 2 shared Y. Luo· 2 shared A. Chandler· 1 shared A. Tabassum· 1 shared B. T. Andresen· 1 shared C. Xie· 1 shared G. Sharma· 1 shared I. Nies· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPharmacology & Toxicology

W. M. Botello-Smith

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2 papers

Recent·Most cited

In silico prediction of ARB resistance: A first step in creating personalized ARB therapy

S. D. Anderson, A. Tabassum, J. K. Yeon, G. Sharma, P. Santos, T. H. Soong, Y. W. Thu, I. Nies, T. Kurita, A. Chandler, A. Alsamarah, R.-S. Kanassatega, Y. Luo, W. M. Botello-Smith, B. T. Andresen

This study predicts ARB resistance by simulating how nsSNPs in the AT1R gene affect drug binding, achieving 60% accuracy in predicting resistance.

bioRxiv · Feb 12, 2020Pharmacology & Toxicology

Polymodal Allosteric Regulation of Type 1 Serine/Threonine Kinase Receptors via a Conserved Electrostatic Lock

W. M. Botello-Smith, A. Alsamarah, P. Chatterjee, C. Xie, J. Lacroix, J. Hao, Y. Luo

This paper identifies a conserved electrostatic lock in STKR1 kinases that regulates kinase activity through a salt-bridge, showing how phosphorylation, FKBP12 dissociation, and mutations disrupt this lock to cause leaky signaling.

bioRxiv · Jul 31, 2017Biophysics